Results 81 to 90 of about 339 (184)

E-ABIN: an explainable module for anomaly detection in biological networks. [PDF]

NAR Genom Bioinform
Lomoio U, Mazza T, Veltri P, Guzzi PH.
europepmc   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

deepNGS navigator: exploring antibody NGS datasets using deep contrastive learning. [PDF]

Bioinformatics
MohammadiPeyhani H, Lee E, Bonneau R, Gligorijevic V, Lee JH.   +4 more
europepmc   +1 more source

Quantifying common and distinct information in single-cell multimodal data with Tilted Canonical Correlation Analysis. [PDF]

Proc Natl Acad Sci U S A, 2023
Lin KZ, Zhang NR.
europepmc   +1 more source

Unconventional Hysteretic Charge Filling in Moiré‐Reconstructed Helical Trilayer Graphene

Advanced Science, EarlyView.
In helical trilayer graphene, sequential twisting reconstructs the moiré landscape into periodic domains separated by aperiodic boundaries. Longitudinal transport reveals sweep‐direction‐dependent hysteresis, while the Hall response traces this behavior to hysteretic charge filling at the aperiodic boundaries.
Hangyeol Park, Junhyeok Oh, Rasoul Ghadimi, Chiranjit Mondal, Yungi Jeong, Won Beom Choi, Kenji Watanabe, Takashi Taniguchi, Bohm‐Jung Yang, Joonho Jang   +9 more
wiley   +1 more source

Unveiling Early Signs of Preclinical Alzheimer's Disease Through ERP Analysis with Weighted Visibility Graphs and Ensemble Learning. [PDF]

Bioengineering (Basel)
Liu Y, Xia J, Kan Z, Zhang J, Toprani S, Brewer JB, Kutas M, Liu X, Olichney J.   +8 more
europepmc   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Probabilistic greedy algorithm solver using magnetic tunneling junctions for traveling salesman problem. [PDF]

Nat Commun
Zhang R, Li X, Wan C, Hoffmann R, Hindenberg M, Xu Y, Liu S, Kong D, Xiong S, He S, Vardar A, Dai Q, Gong J, Sun Y, Zheng Z, Kämpfe T, Yu G, Han X.   +17 more
europepmc   +1 more source

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

A novel approach to graph distinction through GENEOs and permutants. [PDF]

Sci Rep
Bocchi G, Ferri M, Frosini P.
europepmc   +1 more source