Results 61 to 70 of about 5,429,485 (293)

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

An Efficient Gene Selection Technique based on Fuzzy C-means and Neighborhood Rough Set [PDF]

, 2014
Selecting genes from microarray gene expression datasets has become an important research, because such data typically consist of a large number of genes and a small number of samples. Avoiding information loss, neighborhood mutual information is used to
Xu, Jiucheng, Ren, Jinyu, Sun, Lin, Xu, Tianhe   +3 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Anomaly Detection Using Correctness Matching Through a Neighborhood Rough Set

, 2016
Abnormal information patterns are signals retrieved from a data source that could contain erroneous or reveal faulty behavior. Despite which signal it is, this abnormal information could affect the distribution of a real data. An anomaly detection method,
Goh, Pey Yun, Wooi Ping Cheah, Pey Yun Goh, Shing Chiang Tan, Cheah, Wooi Ping, Tan, Shing Chiang   +5 more
core   +1 more source

Hybrid data attribute reduction based on neighborhood rough set

Journal of Intelligent Systems
The attribute reduction in rough set theory has considerable value in areas such as pattern classification, knowledge extraction, and data mining. Hybrid information systems usually contain discrete classification attributes and continuous numerical ...
Wei Caixin, Wang Pei, Li Qingguo
doaj   +1 more source

Neighborhood Rough Set based Multi-document Summarization

CoRR, 2021
This research paper proposes a novel Neighbourhood Rough Set based approach for supervised Multi-document Text Summarization (MDTS) with analysis and impact on the summarization results for MDTS. Here, Rough Set based LERS algorithm is improved using Neighborhood Rough Set which is itself a novel combination called Neighborhood-LERS to be experimented ...
openaire   +3 more sources

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Multilabel Feature Selection Based on Fisher Score with Center Shift and Neighborhood IntuitionisticFuzzy Entropy [PDF]

Jisuanji kexue
The edge samples in the existing multilabel Fisher score models affect the classification effect of the algorithm.It has the available virtues of stronger expression and resolution when using neighborhood intuitive fuzzy entropy to deal with uncertain ...
SUN Lin, MA Tianjiao
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Properties and Approximation Distribution Reductions in Multigranulation Rough Set Model

, 2017
Some properties of approximation sets are studied in multi-granulation optimist model in rough set theory using maximal compatible classes. The relationships between or among lower and upper approximations in single and multiple granulation are compared ...
Properties and Approximation Distribution Reductions in Multigranulation Rough Set Model
core   +1 more source