Results 91 to 100 of about 206,749 (287)

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

open access: yesAdvanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung   +39 more
wiley   +1 more source

Neo-liberalism and health care

open access: yes, 2007
Neo-liberal political-economic ideology, theory and practice have had an immense influence on public and private life across the world, including the delivery of health care, and neo-liberalism has become the dominant economic paradigm. Market practices,
Ruthjersen, Anne Linda
core  

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

open access: yesAdvanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei   +18 more
wiley   +1 more source

PERAN PEMERINTAH DAN PARTISIPASI MASYARAKAT DALAM PERENCANAAN PEMBANGUNAN DAERAH [PDF]

open access: yes, 2017
This study aims to determine the role of the Government and People's Participation in Development Planning in the District Gunungsari, especially on Musrenbang village, in the village of Taman Sari subdistrict Gunungsari West Lombok regency.
Dr, Wahyunadi   +2 more
core   +1 more source

On an Increasingly Yield Curve of Knowledge

open access: yesStudies in Business and Economics, 2018
The paper examines the behaviour of the yield curve of the knowledge considered as production factor. The concepts of complementarity and substitutability among classical production factors are revisited in order to put the bases to analyse the special ...
Dinga Emil
doaj   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

open access: yesAdvanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie   +20 more
wiley   +1 more source

Neo-Functionalism Reassessed: Suggesting a Synthesis of European Integration Theory

open access: yes, 1998
How are we to understand processes of European integration? There are a number of theories that attempt to shed-light on the integration process each considering that a particular variant of social existence provides the best means of interpretation ...
Howell, K.E.
core  

Does protection policy actually produce equality among labours? A tentative rules approach to the answers protective problems migrant labour : case migrant labours from East Java, Indonesia [PDF]

open access: yes, 2018
<p align="center"> </p><p><strong>Purpose</strong> - The purpose of this paper is to analysis effectiveness of the protective rule and their practical effects.</p><p><strong>Design/approach</strong> -
Anita Kristina, Kristina, Anita
core   +1 more source

Neo-liberalism, human capital theory and the right to education: Economic interpretation of the purpose of education

open access: yesSocial Sciences and Humanities Open
With the end of WW II, a new world order emerged that recognised the significance of human rights as part of the remedial measures to institute global peace.
Obinna Christian Edeji
doaj   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

open access: yesAdvanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding   +7 more
wiley   +1 more source

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