Results 151 to 160 of about 11,952,562 (245)

Mapping Proton-Coupled Electron Transfer With Real Space Coordinates. [PDF]

Angew Chem Int Ed Engl
Šrut A, Diefenbach M, Kronenberger ML, Lear BJ, Krewald V.   +4 more
europepmc   +1 more source

Spatial Dynamics of Tourism Sustainability in EU Member States

Sustainable Development, EarlyView.
ABSTRACT This study introduces a synthetic indicator of tourism sustainability for the EU, bridging the gap between institutional monitoring and academic research. By applying the PROMETHEE II method to rank the 27 Member States in 2019 and 2023, the research transforms static data into a dynamic roadmap of post‐pandemic recovery. The findings reveal a
M. Rosario González‐Rodríguez, M. Carmen Díaz‐Fernández   +1 more
wiley   +1 more source

Efficient and robust optimization of nuclear and electronic orbitals within the nuclear Hartree product representation. [PDF]

J Chem Phys
Chow M, Paenurk E, Hammes-Schiffer S.
europepmc   +1 more source

Design, synthesis and activity evaluation of tetrahydroisoquinoline‐based programmed cell death ligand 1 inhibitors

Smart Molecules, EarlyView.
Based on a 3D‐quantitative structure‐activity relationship pharmacophore model, structural optimization of Y6 yielded Y7f. Mechanistic studies revealed that Y7f acted as a programmed death receptor 1/programmed cell death ligand 1 (PD‐L1) interaction inhibitor by inducing PD‐L1 dimerization. Y7f restored T‐cell function.
Menglin Yu, Sen Cai, Yanyan Pan, Heshuang Wang, Fengwu Zhang, Aiyu Ma, Shixuan Lv, Xiuhan Guo, Shisheng Wang, Qiling Song, Chunyan Ma, Shuai Wang, Li Zhang, Jian Wang, Qingwei Meng, Yueqing Li   +15 more
wiley   +1 more source

Two-stage ROM: a hybrid reduced order model for offline and online efficiency. [PDF]

Adv Model Simul Eng Sci
Dhopeshwar R, Bansal H, Veroy K.
europepmc   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

A simple technique for characterizing flexible materials using pressurised tubes. [PDF]

Sci Rep
Rubio M, Anatol J, Barrios-Collado C, Herrada MÁ.   +3 more
europepmc   +1 more source

EE2 and the Fish Brain: Age‐Dependent Impact of 17α‐Ethinylestradiol on Brain Cell Proliferation and Behavior in Sea Bass Larvae

Environmental Toxicology, EarlyView.
ABSTRACT Endocrine‐disrupting chemicals (EDCs), such as 17α‐ethinylestradiol (EE2), have raised concerns about their potential effects on aquatic organisms, particularly during early developmental stages. In this context, the study of behavioral disruption has gained considerable attention, as it may have consequences on individual fitness and ...
Soloperto Sofia, Stephanie Olivier, Céline Thomasse, Christophe Minier, Marie‐Pierre Halm‐Lemeille, Christelle Jozet‐Alves, Salima Aroua   +6 more
wiley   +1 more source

Non-exposure organ-preserving resection of gastric gastrointestinal stromal tumors using the CLEAN-NET technique. [PDF]

J Minim Invasive Surg
Thongchuam C, Phalanusitthepha C, Chinswangwatanakul V, Akaraviputh T, Methasate A, Swangsri J, Suwatthanarak T.   +6 more
europepmc   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source