Results 91 to 100 of about 2,086 (279)
Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation
Advanced Science, EarlyView.Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong +13 more
wiley +1 more source
Islam Nusantara; Sebuah Kajian Post Tradisionalisme dan Neo Modernisme
Tafáqquh: Jurnal Penelitian dan Kajian Keislaman, 2017 Islamic Nusantara is not new religion, not just the new thought. Islamic Nusantara is the approach resourches of transcendent scientific which have religion character and then mergered by humanism sciences resourches which have humanism character ...
Abdul Basid
doaj
Transacting in the absence of trust : Uncertainty and network patterns in post-communism [PDF]
, 2012 The paper critically discusses the widespread literature focusing on informal post-communist “clans,” “networks,” or “fiefdoms.” Often self-described as determinedly empirical, the “clan” paradigm is crucially shaped by its origins in the analysis of ...
Lehmbruch, B. (Barbara)
core +1 more source
Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines
Advanced Science, EarlyView.Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira +18 more
wiley +1 more source
Association of personality facets and cognition in the Lifelines population-based cohort study. [PDF]
J Psychiatr Res, 2023 Marcolini S +3 more
europepmc +1 more source
The creation of Lubaland: missionary science and Christian literacy in the making of the Luba Katanga in Belgian Congo [PDF]
, 2016 This article examines the role of missionary social scientific research and Protestant Christian literacy in the making of the Luba Katanga ethnicity in colonial Belgian Congo.
Maxwell, D
core +2 more sources
Advanced Science, EarlyView.Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han +6 more
wiley +1 more source
Right-wing populism, Euroscepticism, and neo-traditionalism in Central and Eastern Europe
, 2022 The electoral successes of nationalist right-wing populist parties in Hungary and Poland have provoked concern regarding the reasons for the rise of populism. In this context, one may mention the refugee crisis and the perception of immigrants as economic competitors and cultural strangers. In Central and Eastern Europe, where nationalism mainly has an
openaire +3 more sources
Advanced Science, EarlyView.In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia +11 more
wiley +1 more source
La nueva crisis de la filología editorial: cultura del manuscrito, scribal version, literatura medieval [PDF]
, 2008 El presente ensayo examina el complejo de inferioridad que la \ud disciplina editorial castellana asocia a su tardía incorporación de la metodología neo-lachmanniana trayendo a la superficie una posición divergente y \ud polémica formulada por Hans ...
Altschul, Nadia
core +2 more sources