Results 81 to 90 of about 2,086 (279)

A Conjugation Delivery System of Macrophages and Platelet Pharmacytes Promotes Regeneration After Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
A macrophage–platelet conjugation system (M‐P‐NPs@PPARγ) targets injure tissue to co‐deliver platelet mitochondria and PPARγ‐encoding NPs. This strategy boosts the macrophage energy supply and restores lipid homeostasis, leading to synergistically enhanced efferocytosis and tissue repair Abstract Mitochondrial dysfunction occurs in macrophages with ...
Haoli Wang   +18 more
wiley   +1 more source

The Problem of Attitudes towards History in the Theory of Architecture of Postmodernism

open access: yesAcademia: Архитектура и строительство, 2019
The article contains a study of changes in the attitude to history in the foreign architecture of the twentieth century, in connection with the radical transformation of the perception of categories of time.
Alexey A. Khudin
doaj   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

open access: yesAdvanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong   +15 more
wiley   +1 more source

Developing Social Citizenship? A Case Study of Education and Health Services in Yantian Village, Guangdong [PDF]

open access: yes, 2012
This paper uses a case study of the evolution of education and healthcare provision in Yantian Village, Guangdong Province to examine broader trends in China’s evolving social policies.
Saich, Anthony
core  

A Perspective on the Applications of Triphasic Gas Storage in Electrochemical Systems

open access: yesAdvanced Science, EarlyView.
Gas storage in microporous materials positioned locally at an electrode or electrocatalyst surface enhances electrochemical processes. Abstract Microporous materials store gases under dry conditions (e.g., hydrogen or oxygen via physisorption), but in some cases microporous materials also show triphasic (e.g., in a solid|gas|liquid system) gas storage ...
Zhongkai Li   +9 more
wiley   +1 more source

The new crowd of the dispossessed: factory layoffs and the informalization of the urban economy [PDF]

open access: yes, 2001
This paper contrasts the old "crowd" of the revered urban proletariat from the days of Mao Zedong to the new "crowd" of laid-off workers. It utilizes concepts from the book, CROWDS AND POWER, by Elias Canetti, to characterize the opposed characteristics
Solinger, Dorothy J.
core  

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

open access: yesAdvanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra   +23 more
wiley   +1 more source

Interview with Prof. Jan Kubik: The FATIGUE Project [PDF]

open access: yes, 2017
SCIENTIST-IN-CHARGE AND MANAGING DIRECTOR OF THE FATIGUE PROJECT, PROFESSOR JAN KUBIK, IN CONVERSATION WITH SLOVO’S EXECUTIVE EDITOR BORIMIR TOTEV. Prof.
Kubik, Jan, Totev, Borimir
core  

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