Results 51 to 60 of about 70,281 (310)

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

open access: yesAdvanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li   +4 more
wiley   +1 more source

The Theme of the Five Biscuits: Murphy, Foucault, and Beckett’s Critique of Neoliberalism [PDF]

open access: yesEstudios Irlandeses, 2019
Beckett’s Murphy grew out of “Lightning Calculation”, a short story about biscuits and the tragic incommutability of preference. Beckett likely borrowed this rare Americanism from Thorstein Veblen, who uses it to describe the “neo-classical” economic ...
Dominic Walker
doaj  

Fron Neo-classical Entrepreneur to Socio-economic Organization [PDF]

open access: yes
Despite the growing role that business has played in the development of capitalism, the neo-classical paradigm has largely ignored the concept of organization. This paper illustrates the neo-classical concept of the firm and the entrepreneur.
Reyes Calderón
core  

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

open access: yesAdvanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li   +10 more
wiley   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

open access: yesAdvanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu   +10 more
wiley   +1 more source

Rethinking the economics of capital mobility and capital controls

open access: yesBrazilian Journal of Political Economy, 2009
This paper reexamines the issue of international financial capital mobility, which is today's economic orthodoxy. Discussion is often framed in terms of the impossible trinity.
Thomas I. Palley
doaj   +1 more source

NOW IS NOT THE TIME FOR NEO-CLASSICISM: THE CASE FOR NEO-CLASSICISM

open access: yesTempo
AbstractNeoclassicism is now largely eschewed within New Music. While there seems space in our pluralistic scene for modernist, postmodernist, minimalist, performative and conceptual music, the compositional values of neoclassicism seem out of step and anachronistic.
openaire   +1 more source

The Aggregate Demand, Aggregate Supply, and Endogenous Growth: A Synthetic neo-Kaleckian Model [PDF]

open access: yes
This paper develops a neo-Kaleckian endogenous growth model that incorporates aggregate supply - demand balance and balance between labor force and employment growth.
Thomas I. Palley
core  

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

open access: yesAdvanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li   +7 more
wiley   +1 more source

Investment Ratio and Growth [PDF]

open access: yes
In growth and development policy investment ratio is an important policy instrument. However, there is no well defined framework to determine what should be the investment ratio for a given growth target. This paper explains the potential of Solow (1956)
B Bhaskara Rao
core  

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