Results 61 to 70 of about 92,115 (273)

Carcinoembryonic Antigen Messenger RNA in Pelvic Lavage Fluid Predicts Local Recurrence After Curative‐Intent Resection of Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Pelvic lavage carcinoembryonic antigen (CEA) mRNA was quantified in 178 patients undergoing curative‐intent resection for rectal cancer. Positive pelvic lavage CEA mRNA was significantly associated with local recurrence and provided additional prognostic information beyond circumferential resection margin (CRM) status.
Hiroyuki Asai, Yushi Yamakawa, Kazuyoshi Shiga, Shuhei Uehara, Akira Kato, Takuya Suzuki, Hajime Ushigome, Hiroki Takahashi, Yoichi Matsuo, Shuji Takiguchi   +9 more
wiley   +1 more source

Multicenter randomized controlled trial of neoadjuvant chemoradiotherapy alone or in combination with pembrolizumab in patients with resectable or borderline resectable pancreatic adenocarcinoma

Journal for ImmunoTherapy of Cancer, 2023
Background Pancreatic ductal adenocarcinoma (PDAC) is a challenging target for immunotherapy because it has an immunosuppressive tumor microenvironment.
Craig L Slingluff, Gina R Petroni, Todd Bauer, Nipun Merchant, Osama Rahma, Rawad Elias, Scott Rodig, Matthew H G Katz, Andressa Dias Costa, Brian M Wolpin, Stephanie K Dougan, Chee-Chee Stucky, Kathleen Pfaff, Gauri R Varadhachary, Victoire Cardot-Ruffino, Matthew J Reilley, Patrick Lenehan, Tanios S Bekaii-Saab, Jonathan Andrew Nowak   +18 more
doaj   +1 more source

Impact of Histopathological Response on Outcomes After Surgical Resection Following Carbon‐Ion Radiotherapy for Pancreatic Cancer With Arterial Involvement

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Carbon‐ion radiotherapy (CIRT) provides superior dose distribution and higher biological effectiveness than conventional X‐ray radiotherapy and has emerged as a promising component of multidisciplinary treatment for advanced pancreatic ductal adenocarcinoma (PDAC).
Kenichiro Araki, Norio Kubo, Yuhei Miyasaka, Hayato Ikota, Ryo Muranushi, Mariko Tsukagoshi, Takamichi Igarashi, Masahiko Okamoto, Tatsuya Ohno, Ken Shirabe   +9 more
wiley   +1 more source

Preoperative radiotherapy in patients with locally advanced esophageal squamous cell carcinoma: a narrative review

Frontiers in Oncology
Neoadjuvant treatments play a crucial role in improving survival rates for patients with locally advanced resectable esophageal cancer. The CROSS and NEOCRTEC5010 trials have shown that neoadjuvant concurrent chemoradiotherapy significantly enhances ...
Yan Lin, Shou-Feng Wang, Huan-Wei Liang, Yang Liu, Wei Huang, Xin-Bin Pan   +5 more
doaj   +1 more source

Association between pretreatment haemoglobin levels and morphometric characteristics of the tumour, response to neoadjuvant treatment and long-term outcomes in patients with locally advanced rectal cancers [PDF]

, 2013
Aim The study was carried out to investigate whether pretreatment haemoglobin (Hb) levels act as a biomar- ker in the management of patients with locally advanced rectal cancer.
Shabaan, A, Khan, AA, R. Glynne-Jones, Klonizakis, M, Glynne-Jones, R, A. A. Khan, M. Klonizakis, A. Shabaan   +7 more
core   +1 more source

Impact of Postoperative Infectious Complications on Long‐Term Survival After Curative Resection for Colorectal Cancer: A Multicenter Study in the Minimally Invasive Era

Annals of Gastroenterological Surgery, EarlyView.
Postoperative infectious complications (PICs) have been associated with poor long‐term outcomes after colorectal cancer surgery, but evidence in the modern minimally invasive era remains limited. In this multicenter cohort of 5377 patients undergoing curative resection, PICs were independently associated with worse overall survival and relapse‐free ...
Takehito Yamamoto, Ryosuke Mizuno, Yoshiro Itatani, Tetsuya Shiota, Masahiro Yamada, Tadayoshi Yamaura, Mami Yoshitomi, Kazutaka Obama   +7 more
wiley   +1 more source

[Occupational cholangiocarcinoma in a printer that responded to neoadjuvant chemoradiotherapy].

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2015
A 42-year-old man working at a printing company was referred to our hospital for examination and treatment of icterus. We diagnosed resectable hilar cholangiocarcinoma and provided neoadjuvant chemoradiotherapy, extended right hepatectomy, and extrahepatic bile duct resection.
NAKAGAWA, Kei, KATAYOSE, Yu, ISHIDA, Kazuyuki, HAYASHI, Hiroki, MORIKAWA, Takanori, YOSHIDA, Hiroshi, MOTOI, Fuyuhiko, NAITOH, Takeshi, KUBO, Shoji, UNNO, Michiaki   +9 more
openaire   +2 more sources

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

Annals of Gastroenterological Surgery, EarlyView.
This multicenter prospective study provides the first Japanese evidence that circumferential resection margin positivity after minimally invasive surgery is associated with poorer long‐term outcomes in locally advanced rectal cancer. As the cohort predominantly included patients treated with upfront surgery, these findings provide important evidence to
Atsushi Hamabe, Masaaki Ito, Shigeo Toda, Yusuke Suwa, Suguru Hasegawa, Masanori Kotake, Masafumi Inomata, Kazuki Ueda, Atsushi Ogura, Kiichi Sugimoto, Kei Kimura, Koki Otsuka, Tatsuki Noguchi, Koya Hida, Yasumitsu Hirano, Kazushige Kawai, Shigeru Yamagishi, Takeshi Naitoh, Ichiro Takemasa, on behalf of Japan Society of Laparoscopic Colorectal Surgery   +19 more
wiley   +1 more source

Real-world perioperative outcomes of neoadjuvant chemoimmunotherapy in non–small cell lung cancerCentral MessagePerspective

JTCVS Open
Objective: Approximately 30% of non–small cell lung cancers will recur after surgery, highlighting a need for additional perioperative therapies. Several recent clinical trials demonstrated a reduction in non–small cell lung cancer recurrence with the ...
Giorgio Caturegli, MD, Michael F. Kaminski, MD, Maureen Canavan, PhD, Oluwaseun F. Ayoade, MD, MSHA, Benjamin J. Resio, MD, Daniel J. Boffa, MD, MBA   +5 more
doaj   +1 more source

Long‐Term Stoma‐Free Outcomes After Diverting Stoma Closure Following Radiation‐Based Neoadjuvant Treatment for Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Long‐term stoma‐free outcomes after diverting stoma closure in patients who underwent sphincter‐preserving rectal cancer surgery with double‐stapling technique (DST) reconstruction following radiation‐based neoadjuvant treatment remain unclear.
Hidetaka Ichikawa, Shimpei Matsui, Kentaro Sato, Tatsuki Noguchi, Takashi Sakamoto, Toshiki Mukai, Tomohiro Yamaguchi, Takashi Akiyoshi   +7 more
wiley   +1 more source