Results 291 to 300 of about 1,127,554 (354)

Randomized trial of primary debulking surgery versus neoadjuvant chemotherapy for advanced epithelial ovarian cancer (SCORPION-NCT01461850)

International Journal of Gynecological Cancer, 2020
Objective To investigate whether neoadjuvant chemotherapy followed by interval debulking surgery is superior to primary debulking surgery in terms of perioperative complications and progression-free survival, in advanced epithelial ovarian, fallopian ...
A. Fagotti, M. G. Ferrandina, G. Vizzielli, T. Pasciuto, F. Fanfani, V. Gallotta, P. Margariti, V. Chiantera, B. Costantini, S. Gueli Alletti, F. Cosentino, G. Scambia   +11 more
semanticscholar   +1 more source

Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial.

The Lancet Oncology, 2020
BACKGROUND Non-small-cell lung cancer (NSCLC) is terminal in most patients with locally advanced stage disease. We aimed to assess the antitumour activity and safety of neoadjuvant chemoimmunotherapy for resectable stage IIIA NSCLC. METHODS This was an
M. Provencio, E. Nadal, A. Insa, M. García-Campelo, J. Casal-Rubio, M. Dómine, M. Majem, D. Rodríguez-Abreu, A. Martínez-Martí, J. de Castro Carpeño, M. Cobo, G. López Vivanco, E. del Barco, R. Bernabé Caro, N. Viñolas, I. Barneto Aranda, S. Viteri, E. Pereira, A. Royuela, M. Casarrubios, C. Salas Anton, E. Parra, I. Wistuba, V. Calvo, R. Laza-Briviesca, A. Romero, B. Massutí, A. Cruz-Bermúdez   +27 more
semanticscholar   +1 more source

Neoadjuvant chemotherapy followed by surgery in cervical cancer: past, present and future

International Journal of Gynecological Cancer, 2022
Background Cisplatin-based concurrent chemoradiation is the standard treatment for locally advanced cervical cancer. In view of the difficulties associated with implementation of standard radiation protocols in low- and middle-income countries and the ...
R. Miriyala, U. Mahantshetty, A. Maheshwari, Sudeep Gupta   +3 more
semanticscholar   +1 more source

Neoadjuvant nivolumab and chemotherapy in early estrogen receptor-positive breast cancer: a randomized phase 3 trial

Nature Medicine
Patients with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2−) primary breast cancer (BC) have low pathological complete response (pCR) rates with neoadjuvant chemotherapy.
S. Loi, R. Salgado, G. Curigliano, R.I. Romero Diaz, S. Delaloge, Carlos Ignacio Rojas García, Marleen Kok, C. Saura, N. Harbeck, E. Mittendorf, D. Yardley, A. Suárez Zaizar, Facundo Rufino Caminos, A. Ungureanu, Joaquin G Reinoso-Toledo, V. Guarneri, D. Egle, Felipe Ades, M. Pacius, A. Chhibber, Rajalakshmi Chandra, R. Nathani, T. Spires, J. Wu, L. Pusztai, H. McArthur   +25 more
semanticscholar   +1 more source

Overall Survival with Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer.

New England Journal of Medicine
BACKGROUND Neoadjuvant nivolumab plus chemotherapy significantly improved pathological complete response and event-free survival in patients with resectable non-small-cell lung cancer (NSCLC) in a phase 3 trial.
P. Forde, J. Spicer, Mariano Provencio, Tetsuya Mitsudomi, M. Awad, Changli Wang, Shun Lu, E. Felip, Scott J. Swanson, J. Brahmer, Keith Kerr, J. Taube, T. Ciuleanu, F. Tanaka, G. Saylors, Ke-Neng Chen, Hiroyuki Ito, Moishe Liberman, C. Martin, Stephen R Broderick, Lily Wang, Junliang Cai, Quyen Duong, S. Meadows-Shropshire, Joseph Fiore, Sumeena Bhatia, Nicolas Girard   +26 more
semanticscholar   +1 more source

Perioperative Durvalumab with Neoadjuvant Chemotherapy in Operable Bladder Cancer.

New England Journal of Medicine
BACKGROUND Neoadjuvant chemotherapy followed by radical cystectomy is the standard treatment for cisplatin-eligible patients with muscle-invasive bladder cancer. Adding perioperative immunotherapy may improve outcomes.
T. Powles, J. Catto, M. Galsky, H. Al-Ahmadie, J. Meeks, Hiroyuki Nishiyama, Toan Quang Vu, Lorenzo Antonuzzo, P. Wiechno, V. Atduev, Ariel G. Kann, Tae-Hwan Kim, C. Suárez, Chao-Hsiang Chang, F. Roghmann, M. Özgüroğlu, B. Eigl, Niara Oliveira, T. Buchler, Moran Gadot, Y. Zakharia, J. Armstrong, A. Gupta, S. Hois, M. S. van der Heijden   +24 more
semanticscholar   +1 more source

Neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab compared with neoadjuvant chemotherapy alone in patients with early-stage non-small-cell lung cancer (KEYNOTE-671): a randomised, double-blind, placebo-controlled, phase 3 trial.

The Lancet
BACKGROUND At the first interim analysis of the KEYNOTE-671 trial, adding perioperative pembrolizumab to neoadjuvant chemotherapy significantly improved event-free survival in participants with early-stage non-small-cell lung cancer (NSCLC).
J. Spicer, M. Garassino, Heather Wakelee, Moishe Liberman, T. Kato, Masahiro Tsuboi, Se-Hoon Lee, Ke-Neng Chen, C. Dooms, M. Majem, E. Eigendorff, G. Martinengo, O. Bylicki, D. Rodríguez-Abreu, J. Chaft, S. Novello, Jing Yang, A. Arunachalam, S.M. Keller, A. Samkari, Shugeng Gao   +20 more
semanticscholar   +1 more source

Doublet chemotherapy, triplet chemotherapy, or doublet chemotherapy combined with radiotherapy as neoadjuvant treatment for locally advanced oesophageal cancer (JCOG1109 NExT): a randomised, controlled, open-label, phase 3 trial.

The Lancet
BACKGROUND Neoadjuvant therapy is the standard treatment for patients with locally advanced oesophageal squamous cell carcinoma (OSCC). However, the prognosis remains poor and more intensive neoadjuvant treatment might be needed to improve patient ...
Ken Kato, R. Machida, Y. Ito, H. Daiko, Soji Ozawa, Takashi Ogata, H. Hara, T. Kojima, Tetsuya Abe, Takeo Bamba, Masaya Watanabe, H. Kawakubo, Y. Shibuya, Y. Tsubosa, Naoki Takegawa, T. Kajiwara, Hideo Baba, Masaki Ueno, H. Takeuchi, Kenichi Nakamura, Yuko Kitagawa   +20 more
semanticscholar   +1 more source

Preoperative (Neoadjuvant) Chemotherapy

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1986
Clinical and Scientific Considerations in Preoperative (Neoadjuvant) Chemotherapy.- Experimental Adjuvant Chemotherapy: An Overview.- Theoretical Considerations Regarding the Early Use of Adjuvant Chemotherapy.- Experimental Preoperative Chemotherapy.- Implications of Certain Cell Kinetic and Biological Parameters for Preoperative Chemotherapy ...
openaire   +3 more sources

Breast Conservation After Neoadjuvant Chemotherapy

Annals of Surgical Oncology, 2005
Tumor downstaging by preoperative neoadjuvant chemotherapy in patients with locally advanced breast tumors allows breast conservation in women who were previously candidates for mastectomy. Nevertheless, lumpectomy success in such cases cannot be fully achieved.
Siegal, Sadetzki, Bernice, Oberman, Douglas, Zipple, Bella, Kaufman, Shulamit, Rizel, Ilya, Novikov, Moshe Z, Papa   +6 more
openaire   +2 more sources