Results 301 to 310 of about 4,732,777 (361)

Total Neoadjuvant Therapy in Rectal Cancer: A Systematic Review and Meta-analysis of Treatment Outcomes.

Annals of Surgery, 2020
BACKGROUND The addition of induction chemotherapy to concomitant neoadjuvant chemoradiation in locally advanced rectal cancer could increase pathological downstaging and act on occult micrometastatic disease, leading ultimately to a better outcome.
F. Petrelli, F. Trevisan, M. Cabiddu, G. Sgroi, L. Bruschieri, E. Rausa, M. Ghidini, L. Turati   +7 more
semanticscholar   +1 more source

Neoadjuvant Therapy for Resectable Pancreatic Cancer

Annals of Surgery, 2021
Supplemental Digital Content is available in the text Objective: The aim of this study was to pool data from randomized controlled trials (RCT) limited to resectable pancreatic ductal adenocarcinoma (PDAC) to determine whether a neoadjuvant therapy ...
D. L. Birrer, H. Golcher, R. Casadei, S. Haile, R. Fritsch, S. Hussung, T. Brunner, R. Fietkau, T. Meyer, R. Grützmann, S. Merkel, C. Ricci, C. Ingaldi, M. Di Marco, A. Guido, C. Serra, F. Minni, B. Pestalozzi, H. Petrowsky, M. DeOliveira, W. Bechstein, C. Bruns, C. Oberkofler, M. Puhan, M. Lesurtel, S. Heinrich, P. Clavien   +26 more
semanticscholar   +1 more source

Neoadjuvant Therapy for Rectal Cancer

Surgical Oncology Clinics of North America, 2022
The treatment of locally advanced rectal cancer is challenging and requires a multidisciplinary approach. Neoadjuvant treatment has improved local control by the combination of radiotherapy, surgery, and chemotherapy. However, neoadjuvant treatment has not yet been shown to improve overall survival and is associated with toxicities and late sequelae ...
Felipe F, Quezada-Diaz, J Joshua, Smith
openaire   +2 more sources

Randomized Phase II Trial of Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: CAO/ARO/AIO-12.

Journal of Clinical Oncology, 2019
PURPOSE Total neoadjuvant therapy is a new paradigm for rectal cancer treatment. Optimal scheduling of preoperative chemoradiotherapy (CRT) and chemotherapy remains to be established.
E. Fokas, M. Allgäuer, B. Polat, G. Klautke, G. Grabenbauer, R. Fietkau, T. Kuhnt, L. Staib, T. Brunner, A. Grosu, W. Schmiegel, L. Jacobasch, J. Weitz, G. Folprecht, A. Schlenska-Lange, M. Flentje, C. Germer, R. Grützmann, M. Schwarzbach, V. Paolucci, W. Bechstein, T. Friede, M. Ghadimi, R. Hofheinz, C. Rödel   +24 more
semanticscholar   +1 more source

Neoadjuvant Therapy in Esophageal Cancer

Thoracic Surgery Clinics, 2022
Locally advanced esophageal cancer has a dismal prognosis. Surgery remains the cornerstone treatment with 5-year survival rates of approximately 12-39%. Rates of local failure and distant metastases are high following surgical resection of locally advanced tumors.
Shirley, Lewis, Jelena, Lukovic
openaire   +2 more sources

Neoadjuvant Therapy in Rectal Cancer

Diseases of the Colon & Rectum, 2011
The optimal type of neoadjuvant therapy regimen in rectal cancer is contentious.This study aimed to review the impact of neoadjuvant therapy on oncological outcomes and complications (short and long term) in patients undergoing total mesorectal excision for rectal cancer.An electronic search of MEDLINE, PubMed, EMBASE, and the Cochrane Database of ...
Fergal J, Fleming, Lars, Påhlman, John R T, Monson   +2 more
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Neoadjuvant Endocrine Therapy Models

2006
Neoadjuvant therapy is therapy administered before surgical intervention and while the tumor remains in the breast. It may be given to treat large, locally advanced tumors, with the aim of shrinking them and thus making their surgical excision either simply possible or less radical.
Juliette, Murray, William R, Miller, J Michael, Dixon   +2 more
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Neoadjuvant Therapy Versus Adjuvant Therapy

2012
This chapter describes an aspect of study design for oncology clinical trials (and in daily oncology clinical practice), namely, the choice of neoadjuvant therapy, which occurs before surgery, and adjuvant therapy, which occurs after therapy. Neoadjuvant therapy and adjuvant therapy each have specific advantages.
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Neoadjuvant Therapy in Pancreatic Cancer

Cancer Investigation, 2007
Pancreatic cancer is the fourth leading cause of cancer deaths in the United States. Surgical resection offers the only hope of cure, though the addition of chemoradiation in the adjuvant setting has been shown to improve survival over surgery alone. Many patients are unable to receive adjuvant therapy due to prolonged postoperative recovery.
Roderick M, Quiros, Kimberly M, Brown, John P, Hoffman   +2 more
openaire   +2 more sources

Neoadjuvant Therapy of Esophageal Cancer

Surgical Oncology Clinics of North America, 1997
Locally advanced esophageal cancer, potentially curable with surgery or radiotherapy-based treatment, has a poor prognosis because of the eventual development of systemic metastatic disease in the majority of patients. Local recurrence of disease after local treatment modalities is equally problematic.
D H, Ilson, M, Bains, R J, Ginsberg, D P, Kelsen   +3 more
openaire   +2 more sources