Results 41 to 50 of about 60,963 (302)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Magnesiothermic reduction of neodymium oxide through molten alloy non-ideality and hydride precipitation

Communications Materials
Neodymium, a key rare-earth element used in high-performance magnets for electric vehicles and wind turbines, is currently produced via an emission-intensive molten-salt electrolysis process.
Munro J. Alley, Pei Sun, Zhigang Zak Fang   +2 more
doaj   +1 more source

Atomistic study on the pressure dependence of the melting point of NdFe12 [PDF]

, 2020
We investigated, using molecular dynamics, how pressure affects the melting point of the recently theorised and epitaxially grown structure NdFe12. We modified Morse potentials using experimental constants and a genetic algorithm code, before running two-
Chantrell, RW, Evans, RFL, Fischbacher, J, Hrkac, G, Ito, M, Kato, A, Ostler, Thomas, Schrefl, T, Shoji, T, Skelland, C, Westmoreland, SC, Winklhofer, M, Yano, M, Zimanyi, G   +13 more
core   +3 more sources

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Collectivity in Heavy Nuclei in the Shell Model Monte Carlo Approach

, 2013
The microscopic description of collectivity in heavy nuclei in the framework of the configuration-interaction shell model has been a major challenge.
Alhassid, Y., Nakada, H., Özen, C.
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Carbon dioxide-enriched atmosphere diminished the phytotoxicity of neodymium in wheat (Triticum aestivum L.)

Frontiers in Plant Science
IntroductionNeodymium (Nd), a rare earth element (REEs), is widely utilized in industry. Although the detailed biological role of Nd in plant biology is unclear, recent reports have noted its oxidative phytotoxicity at concentrations higher than 200 mg ...
Ahmed M. Saleh, Ahmed M. Saleh, Maha S. A. Haridy, Afrah E. Mohammed, Afrah E. Mohammed, Lewis Ziska, Modhi O. Alotaibi, Modhi O. Alotaibi, Ahmed M. A. Khalil, Mahmoud M. Y. Madany, Hamada Abd Elgawad, Hanaa E. A. Amer   +11 more
doaj   +1 more source

Calcium Niobate Ca(NbO3)2—A New Laser Host Crystal [PDF]

, 1963
Large single crystals of calcium niobate Ca(NbO3)2, grown by the zochralski technique, are transparent and can be doped with rare earth or transition metal ions.
Ballman, A. A., Porto, S. P. S., Yariv, A.   +2 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source