Results 41 to 50 of about 31,396 (305)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Radiogenic neodymium composition of surface sediments from the Arctic Ocean

, 2017
Radiogenic neodymium composition of surface sediments from the Arctic ...
Stein, Ruediger, Ruediger Stein (6885428), Evgenia A Bazhenova (6959651), Fagel, Nathalie, Bazhenova, Evgenia A, Nathalie Fagel (6959654)   +5 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Strontium and neodymium isotopic records of sediment core GeoB3808-6

, 2015
Strontium and neodymium isotopic records of sediment core GeoB3808-
Roger Francois (6963200), Pere Masqué (6969488), Bickert, Torsten, Torsten Bickert (6958880), Zahn, Rainer, Abouchami, Wafa, Lukas Jonkers (7432196), Rainer Zahn (6965303), Thomas, Alexander, Gideon M Henderson (6969485), Wafa Abouchami (1851244), Francois, Roger, Henderson, Gideon M, Ian R Hall (6965300), Hall, Ian R, Jonkers, Lukas, Alexander Thomas (6440303), Masqué, Pere   +17 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Distribution of neodymium isotopes and concentrations during METEOR cruise M77/3

, 2013
Distribution of neodymium isotopes and concentrations during METEOR cruise M77/
Stramma, Lothar, Stichel, Torben, Patricia Grasse (7916258), Roland Stumpf (7973609), Lothar Stramma (6973382), Grasse, Patricia, Frank, Martin, Torben Stichel (7973486), Stumpf, Roland, Martin Frank (7482416)   +9 more
core   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Distribution of neodymium isotopes and concentrations during METEOR cruise M77/4

, 2013
Distribution of neodymium isotopes and concentrations during METEOR cruise M77/
Stramma, Lothar, Stichel, Torben, Patricia Grasse (7916258), Roland Stumpf (7973609), Lothar Stramma (6973382), Grasse, Patricia, Frank, Martin, Torben Stichel (7973486), Stumpf, Roland, Martin Frank (7482416)   +9 more
core   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source