Results 61 to 70 of about 7,040,663 (306)

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Impact of Intervention Program on Nursing Performance Provided for Neonates with Sepsis at Intensive Care Units [PDF]

Egyptian Journal of Health Care, 2017
Background: Sepsis imposes a major threat to newborn infants. It is estimated that sepsis causes over half a million neonatal deaths annually, thereby accounting for about 15% of all neonatal deaths worldwide.
Naglaa Fathy Mohamed Belal, Safaa Salah Ismail, Madiha Hassan Bayoumi   +2 more
doaj   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Neonatal care for nurses and midwives: Principles for practice

, 2022
Written by neonatal nurses and midwives for nurses and midwives, the 2nd edition highlights the collaborative nature of neonatal care and the provision of individualised, developmentally and culturally appropriate, family-centred care.

core   +1 more source

Understanding infant stress in neonatal and pediatric intensive care: a scoping review [PDF]

Infants in intensive care environments encounter numerous stressors which may overlap or occur in close proximity. Recent literature suggests stressful encounters in the neonatal or early infant period are harmful to physiological, functional, and ...
Pintz, Christine, Zhou, Quiping Pearl, Hinds, Pamela S., Darcy-Mahoney, Ashley, Mastropietro, Christopher, Riley, Christine   +5 more
core   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

THE COMPARATIVE ANALYSIS OF MICROBIOLOGICAL MONITORING IN NEONATAL INTENSIVE CARE UNITS IN KRASNIDAR REGIONAL CLINICAL HOSPITAL №2

Кубанский научный медицинский вестник, 2018
Aim. To compare proportion of different microorganisms in neonatal intensive care units and to assess bacterial susceptibility to antimicrobial agents.Materials and methods.
N. E. SHABANOVA, G. YU. MODEL, O. G. NI, I. N. OCHAKOVSKAYA, L. V. PETROVA   +4 more
doaj   +1 more source

Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis

Advanced Science, EarlyView.
OSMR mutations disrupt STAT5 signaling and AKR1B10‐mediated lipid metabolism, leading to lipid accumulation and protein aggregation in keratinocytes. This metabolic reprogramming drives amyloid deposition in primary localized cutaneous amyloidosis, revealing a mechanistic link between lipid dysregulation and amyloidogenesis.
Huiting Liu, Wen Zheng, Chao Yang, Tao Yang, Qiuyu Chen, Ping Lu, Huan Yang, Jun Liu, Bin Yang   +8 more
wiley   +1 more source

Parental concern and distress about infant pain [PDF]

, 2004
Objective: To describe parent views on infant pain care and to explore relations between parents’ experience of their infant’s pain care and parental stress. Design: Descriptive, cross sectional survey.
Winter, I, Cox, S., Winter, I., Franck, L.S., Allen, A., Allen, A, Cox, S, Franck, L S   +7 more
core  

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source