Results 91 to 100 of about 222,381 (312)

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

Neonatal Mortality in Developing Countries: What can we learn from DHS data?

open access: yes, 2005
This study explores the potential contribution of DHS data in improving knowledge of trends in neonatal mortality in developing countries. It outlines the causes and possible consequences of sampling and non-sampling error in survey data of this nature ...
Hall, Sarah
core  

Recent advances in the construction of humanized animal models and applications in translational medicine

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Longitudinal Phenotypic Trajectories in GNAO1‐Related Disorders: Defining Disease Progression and Clinical Profiles

open access: yesAnnals of Neurology, EarlyView.
Objective Pathogenic variants in GNAO1 cause a spectrum of epilepsy, movement disorders, and developmental impairment. Clinical heterogeneity complicates prognosis and therapeutic development. We present the first longitudinal natural history study of GNAO1‐related disorders (GNAO1‐RD) to delineate phenotypic trajectories. Methods Sixty‐six individuals
Jana Domínguez‐Carral   +52 more
wiley   +1 more source

A Study On Neonatal Mortality In Jamnagar District Of Gujarat

open access: yesIndian Journal of Community Medicine, 1998
Research question: Which are the maternal, socio-demographic and neonatal attributes responsible for neonatal mortality in rural areas of Gujarat? Objectives: (i) To know various maternal, socio-demographic and neonatal factors responsible for neonatal ...
Yadav Sudha, Yadav B.S
doaj  

Phosphatidylglycerol and neonatal mortality and morbidity

open access: yesJournal of Obstetrics and Gynaecology, 1986
In spite of major improvements in neonatal intensive care, mortality and morbidity remain a problem for the very preterm baby. In a study of 168 babies born before 36 weeks the presence of phosphatidylglycerol (PG) as a marker of fetal lung maturity in amniotic fluid or pharyngeal aspirate was associated with a lower requirement for ventilatory support
M J, Whittle   +4 more
openaire   +2 more sources

Over the edge: Empirical evidence for the cliff‐edge model of obstetric selection

open access: yesThe Anatomical Record, EarlyView.
Abstract The cliff‐edge model of obstetric selection maintains that larger neonates and smaller birth canals confer a positive selective advantage until labor becomes obstructed and vaginal delivery is no longer possible, eliciting an abrupt reduction in fitness.
Laura M. Watson   +6 more
wiley   +1 more source

Demographic differentials in births assisted by trained midwives in Nineteenth-Century Sweden: What difference did it make for infant survival?

open access: yesSexual & Reproductive Healthcare
Objectives: This study examines the influence of social and demographic factors on the utilization of trained midwives in Sweden during the latter half of the nineteenth century.
Lena Karlsson
doaj   +1 more source

Tendências da mortalidade infantil no Município de Guarulhos: análise do período de 1971 a 1998 Trends of infant mortality in the city of Guarulhos: 1971 to 1998

open access: yesRevista Brasileira de Epidemiologia, 2001
INTRODUÇÃO: Nas últimas décadas, o coeficiente de mortalidade infantil vem apresentando uma tendência de queda, principalmente às custas do componente pós-neonatal.
Ermelinda Antonia Tomé   +1 more
doaj   +1 more source

Developmental differences in cortical bone structure in chimpanzee and human femora reflect early locomotor independence in humans

open access: yesThe Anatomical Record, EarlyView.
Abstract The cortical bone structure of long bone diaphyses changes throughout growth via skeletal modeling and has important implications for bone strength and structural integrity. Ontogenetic trends in diaphyseal structure have been identified in both chimpanzees and humans but it is not yet clear how these trends compare given notable differences ...
Karen R. Swan   +3 more
wiley   +1 more source

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