Results 131 to 140 of about 6,914,193 (304)

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Neonatal mortality in countries of the Americas, 2000–2020: trends, inequalities, and target-setting

Revista Panamericana de Salud Pública
Objective. To analyze temporal trends and inequalities in neonatal mortality between 2000 and 2020, and to set neonatal mortality targets for 2025 and 2030 in the Americas. Methods.
Pablo Duran, Patricia Soliz, Oscar J. Mujica, Daniel A. Cueva, Suzanne J. Serruya, Antonio Sanhueza   +5 more
doaj   +1 more source

Neonatal Mortality and Associated Factors at a Tertiary-Level Neonatal Intensive Care Unit in Mogadishu, Somalia: A Retrospective Study [PDF]

Mohamud Eyow Ali,1 Yusuf Omar Hassan,2 Mohammed AM Ahmed,3 Liban Bile Mohamud4 1Department of Pediatrics, Mogadishu Somali Turkish Training and Research Hospital, Mogadishu, Somalia; 2Department of Pediatrics and Child Health, Mogadishu University ...
Hassan YO, Ali ME, Mohamud LB, Ahmed MA
core  

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Birth-Based vs Fetuses-at-Risk Approaches for Assessing Neonatal Mortality Rate by Race.

JAMA Pediatr, 2023
Wu B, Taylor S, Shabanova V, Hawley NL.
europepmc   +1 more source

Annual rate of reduction in the under-five mortality rate compared to annual rate of reduction in the neonatal mortality rate over the periods 1990–2000, 2000–2010, and 1990–2010.

, 2012
Annual rate of reduction in the under-five mortality rate compared to annual rate of reduction in the neonatal mortality rate over the periods 1990–2000, 2000–2010, and 1990–2010.
Kenneth Hill (49825), Mikkel Z. Oestergaard (141735), Danzhen You (139196), Mie Inoue (141732)   +3 more
core   +1 more source

Maternal Dipyrone Exposure and Risk of Major Congenital Malformations, Adverse Perinatal and Postnatal Outcomes: A Population‐Based Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pain and fever are common in pregnancy. Dipyrone is widely used in Europe, Latin America, and parts of Asia, but is banned in other countries due to concerns about agranulocytosis. Evidence on its safety in pregnancy remains limited and inconsistent. This study aimed to evaluate whether maternal dipyrone use during the first‐ and third‐trimesters is ...
Itamar Ben Shitrit, Daphna Idan, Ariel Avraham Hasidim, Tal Michael, Amalia Levy, Gali Pariente, Eitan Lunenfeld, Sharon Daniel   +7 more
wiley   +1 more source

Rates and Causes of Neonatal Mortality In North-West of Iran

Iranian Journal of Pediatrics
Background: The neonatal mortality rate (NMR) is a crucial indicator of a country's population health Objectives: This study aims to assess the rates and causes of NMR in West Azerbaijan. Methods: This population-based cross-sectional study utilizes data from the Child Mortality Surveillance System (CMSS) spanning from 2013 to 2022.
Marjan Hosseinpour, Farzad Maleki, Hamidreza Farrokh-Eslamlou, Zahra Sahebazzamani, Javad Aghazadeh, Rasoul EntezarMahdi, Zahra Ahmadnezhad, Shahsanam Gheibi   +7 more
openaire   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Trends in Mortality in an Australian Tertiary Surgical Neonatal Intensive Care Unit

, 2018
Aim: The aim of the study was to estimate mortality rate and trend in the neonate admitted to a surgical neonatal intensive care unit.Methods: This study was a retrospective cohort analysis of all neonatal (from birth toResults: There were a total of ...
Amit Trivedi, Joseph Kiran Tauro, Robert Halliday, Karen Walker, Vishal Jatana   +4 more
core   +1 more source