Results 51 to 60 of about 6,914,193 (304)

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Neonatal mortality in developing countries: an analysis of trends and determinants

, 2009
There is limited understanding of how both trends and determinants of neonatal mortality vary from post-neonatal mortality, and more specifically how health care variables are associated with deaths in the first month of life.
Neal, Sarah Elizabeth
core   +1 more source

Time trends in perinatal mortality, stillbirth, and early neonatal mortality rates of first and second twins.

, 2022
(a) Perinatal mortality rate, (b) Stillbirth rate, (c) Early neonatal mortality rate.
Eijiro Hayata (9955279), Masahiko Nakata (13149728), Mineto Morita (13149731)   +2 more
core   +1 more source

Periostin‐CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy

Advanced Science, EarlyView.
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu, Ruotong Li, Xiaoyue Zhang, Dandan Chen, Jianmeng Yang, Mengmeng Li, Yuhan Yin, Ya Wang, Yuqiu Tian, Haoling Yan, Dan Cui, Jiangping Song, Gaoliang Ouyang   +12 more
wiley   +1 more source

Neonatal and "perinatal" mortality rates by birth weight. [PDF]

BMJ, 1977
Neonatal and "perinatal" mortality rates by birth weight were compared for Sheffield and for England and Wales. The fall in neonatal mortality rate for Sheffield infants weighing 2500 g or less was partly due to the excessive fall in numbers in the 1000 g or less group: this effect was also present in England and Wales but was less pronounced ...
openaire   +2 more sources

Perinatal mortality in rural Burkina Faso: a prospective community-based cohort study. [PDF]

, 2010
BACKGROUND: There is a scarcity of reliable data on perinatal mortality (PNM) in Sub-Saharan Africa. The PROMISE-EBF trial, during which we promoted exclusive breastfeeding, gave us the opportunity to describe the epidemiology of PNM in Banfora Health ...
Emmanuel Zabsonré, Cousens, Simon, Meda, Nicolas, Halvor Sommerfelt, Tylleskär, Thorkild, Diallo, Abdoulaye Hama, PROMISE-EBF Study Group, Meda Nicolas, Zabsonré, Emmanuel, null null, Abdoulaye Hama Diallo, Cousens Simon, Tylleskär Thorkild, Simon Cousens, Diallo Abdoulaye, Sommerfelt, Halvor, Thorkild Tylleskär, Zabsonré Emmanuel, Sommerfelt Halvor, Nicolas Meda   +19 more
core   +2 more sources

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Risk factors associated with high infant and child mortality in Lesotho [PDF]

, 2011
This study uses the 2004 and 2009 Lesotho Demographic and Health Surveys (LDHS) to: 1) identify the risk factors that affect mortality at neonatal, post-neonatal, and child ages, and, specifically, to determine the effect of mother’s HIV status on child ...
Mokoena, Mathabang P
core   +1 more source

Effectiveness of a home-based counselling strategy on neonatal care and survival : a cluster-randomised trial in six districts of rural southern Tanzania [PDF]

, 2015
We report a cluster-randomised trial of a home-based counselling strategy, designed for large-scale implementation, in a population of 1.2 million people in rural southern Tanzania.
Schellenberg, David, Donat Shamba, Tanya Marchant, Seyi Soremekun (298266), Kizito Shirima, Manzi, Fatuma, Mkumbo, Elibariki, Fatuma Manzi (247273), Marchant, Tanya, Hill, Zelee, Zelee Hill (298272), Marcel Tanner (33894), Marcel Tanner, Seyi Soremekun, Fatuma Manzi, Hassan Mshinda, Suzanne Penfold (358479), Jennie Jaribu (801365), Yuna Hamisi (801366), Soremekun, Seyi, Schellenberg, Joanna, Elibariki Mkumbo (801362), Kizito Shirima (801363), Simon Cousens, Hanson, Claudia, Joanna Schellenberg, Penfold, Suzanne, David Schellenberg (33891), Mshinda, Hassan, Jaribu, Jennie, Tanner, Marcel, Hamisi, Yuna, Cousens, Simon, Claudia Hanson (373377), Zelee Hill, Jennie Jaribu, Yuna Hamisi, Simon Cousens (208213), Elibariki Mkumbo, Hassan Mshinda (32778), David Schellenberg, Donat Shamba (801364), Tanya Marchant (92398), Joanna Schellenberg (418020), Suzanne Penfold, Claudia Hanson, Shirima, Kizito, Shamba, Donat, Shirima, K, Jaribu Jennie, Soremekun, S, Shamba, D, Hamisi Y, Hill Z, Schellenberg David, Shirima K, Soremekun S, Manzi Fatuma, Shamba Donat, Marchant Tanya, Shirima Kizito, Hanson Claudia, Soremekun Seyi, Tanner Marcel, Hanson C, Penfold S, Hamisi, Y, Tanner M, Shamba D, Manzi F, Mkumbo E, Mshinda H, Mkumbo, E, Marchant T, Hamisi Yuna, Mshinda Hassan, Cousens Simon, Schellenberg Joanna, Manzi, F, Jaribu J, Penfold, S, Mkumbo Elibariki, Schellenberg D, Hanson, C,, Penfold Suzanne, Schellenberg J, Hill, Z, Cousens S, Hill Zelee, Jaribu, J   +89 more
core   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source