Results 171 to 180 of about 2,311,467 (287)

Bridging Parental Perceptions and Experiences of Family‐Centered Care in the Pediatric Intensive Care Unit: A Mixed‐Methods Study

open access: yesJournal of Clinical Nursing, Volume 35, Issue 10, Page 4232-4248, October 2026.
ABSTRACT Aim To examine parents' perceptions and experiences of family‐centered care in a pediatric intensive care unit and explore how communication, participation in care, and contextual factors shape these experiences. Design An explanatory sequential mixed‐methods design was used.
Merve Azak   +3 more
wiley   +1 more source

Metformin Inhibits Trophoblast Ferroptosis by Suppressing ATF2 and Activating the PI3K/Akt/Nrf2 Pathway to Improve Gestational Diabetes Mellitus

open access: yesThe FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Metformin suppresses ATF2 expression, activating the PI3K/Akt pathway and promoting Nrf2 nuclear translocation. This upregulates GPX4, inhibiting ferroptosis in trophoblast cells. Erastin blocks system Xc−, depleting GSH and promoting ferroptosis. LY294002 and ML385 inhibit the pathway, validating the mechanism.
Dandan Xia   +6 more
wiley   +1 more source

Recognition of Patau Syndrome (Trisomy 13) Based on Clinical Features in a Resource‐Limited Setting: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Patau syndrome (trisomy 13) is a life‐limiting chromosomal disorder with multiple congenital anomalies. We report a term male neonate with bilateral cleft lip and palate, aplasia cutis congenita, postaxial polydactyly, hypotonia, congenital heart disease, and presumed neonatal sepsis.
Sayed Hussain Amiri   +4 more
wiley   +1 more source

Bereaved Parents' Perspectives on Quality Pediatric End‐of‐Life Care: A Scoping Review

open access: yesCochrane Evidence Synthesis and Methods, Volume 4, Issue 5, September 2026.
ABSTRACT Background Pediatric end‐of‐life care profoundly impacts families, yet existing reviews on bereaved parents' experiences lack methodological rigor and comprehensive synthesis. Identifying key quality indicators from parents' perspectives is essential for improving care.
Rawnaq Almahadeen   +6 more
wiley   +1 more source

Pragmatic Phenotype–Electrophysiology–Genomics Integration in Pediatric Congenital Myasthenic Syndromes: Insights From 36 Patients in a Single‐Center Study in China

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
In 36 Chinese pediatric CMS patients, integrated phenotype, RNS, and genomic assessment revealed marked genetic heterogeneity across 17 CMS‐associated genes and frequent VUS‐related uncertainty. Genotype‐informed therapy improved MG‐ADL scores, while CHAT‐CMS identified a high‐risk subgroup for early respiratory failure and mortality.
Liya Cui   +18 more
wiley   +1 more source

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