Results 121 to 130 of about 147,877 (305)

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Programa de triagem auditiva neonatal universal no Hospital Universitário Polydoro Ernani de São Thiago em 2006. [PDF]

, 2008
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Vargas, Juliano Córdova
core  

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Neonatal screening for cystic fibrosis using blood trypsin with complementary meconium lactase: an advisable strategy for the population of southern Europe

, 1995
Introduction: Neonatal screening for cystic fibrosis (CF) is now included in several newborn screening programs, based on the view that early presymptomatic diagnosis and therapy for CF reduces the morbidity and mortality from that disease.
Pedrotti D, Giglio L, Faraguna D, Mengarda G, Mastella G., Pederzini F, CABRINI, GIULIO   +6 more
core  

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Neonatal screening for MPS disorders in Latin America : a survey of pilot initiatives [PDF]

, 2020
Newborn screening enables the diagnosis of treatable disorders at the early stages, and because of its countless benefits, conditions have been continuously added to screening panels, allowing early intervention, aiming for the prevention of irreversible
Pereira, Danilo, Netto, Alice Brinckmann Oliveira, Kubaski, Francyne, Sousa, Inês, Facchin, Ana Carolina Brusius, Polo, Giulia, Giugliani, Roberto, Souza, Alexandre, Amorim, Tatiana, Ranieri, Enzo, Burlina, A., Trometer, Joe, Tomatsu, Shunji   +12 more
core  

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Editorial: Biomarkers to predict, prevent and find the appropriate treatments of disorders in childhood

Frontiers in Pediatrics, 2022
Kristin Skogstrand, Nis Borbye-Lorenzen, Marie Bækvad-Hansen, Ulrik Lausten-Thomsen   +3 more
doaj   +1 more source

Postpartum depression screening in the Neonatal Intensive Care Unit: program development, implementation, and lessons learned

, 2016
Amanda S Cherry,1 Ryan T Blucker,1 Timothy S Thornberry,2 Carla Hetherington,3 Mary Anne McCaffree,3 Stephen R Gillaspy1 1Department of Pediatrics, Section of General and Community Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City,
Gillaspy SR, Cherry AS, McCaffree MA, Blucker RT, Thornberry TS, Hetherington C   +5 more
core  

Implantação do programa de triagem auditiva neonatal no Hospital Universitário da Universidade Federal de Santa Catarina [PDF]

, 2005
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Mattos, Wilian Maduell de
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