Results 171 to 180 of about 345,481 (316)

Platelet physiology and immunology: pathogenesis and treatment of classical and non-classical fetal and neonatal alloimmune thrombocytopenia

, 2019
Zi Yan Chen, Brigitta Elaine Oswald, Jade A. Sullivan, Fatima Zohra Dahmani, Yfke Pasman, Zhenze Liu, Pingguo Chen, Heyu Ni   +7 more
openalex   +1 more source

Cidea Targeting Protects Cochlear Hair Cells and Hearing Function From Drug‐ and Noise‐Induced Damage

Advanced Science, EarlyView.
Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang, Ruiying Qiang, Yuan Zhang, Jinxian Wan, Chen Tao, Ying Dong, Xujun Tang, Li Xu, Hairong Xiao, Yanqin Lin, Wei Tong, Ying Ma, Yongming Wang, Peng Li, Renjie Chai   +14 more
wiley   +1 more source

When Neonates Require Anesthesia for the Management of Airway-Related Problems. [PDF]

Cureus
Maio B, Silva M.
europepmc   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Successful dual therapy of aztreonam and ceftazidime-avibactam for multidrug-resistant <i>Stenotrophomonas maltophilia</i> infection in a preterm neonate: A life-saving approach. [PDF]

J Int Med Res
Alghamdi AO, Algethami AS, Aljuaeed MS, Alkhammash FM, Almalki FM, Alharthi SA, Aljaed NM, Abosabie SA, Abosabie SA, Kamal NM.   +9 more
europepmc   +1 more source

Unusual feature of neonatal hypernatremic dehydration due to microvillus inclusion disease: a case report [PDF]

, 2018
F. Khalsi, Mohamed Riadh Boukhris, Inès Brini, Jean‐Pierre Hugot, Patsy Dominique Berrebi, Khédija Boussetta   +5 more
openalex   +1 more source

Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes

Advanced Science, EarlyView.
In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu, Wenpin Qin, Jialu Gao, Yihan Guo, Xiaoxiao Han, Zhangyu Ma, Xiaokang Zhang, Jie He, Jing Liu, Bo Gao, Changjun Li, Lina Niu, Jianfei Yan, Kai Jiao   +13 more
wiley   +1 more source

Molecular identification and diagnostic challenges of <i>Kodamaea ohmeri</i> fungemia in a neonate - first report from Pakistan. [PDF]

Iran J Microbiol
Farooq H, Nizamuddin S, Qazi R, Malik N, Sultan F.   +4 more
europepmc   +1 more source

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Treacher-Collins Syndrome With Anorectal Malformation: A Rarity and a Challenge for the Surgical Team. [PDF]

Cureus
Monyei MO, Edena ME, Olodiama F, Ekene OA.   +3 more
europepmc   +1 more source