Results 231 to 240 of about 639,502 (342)

The Prevalence and Management of Dehydration amongst Neonatal Admissions to General Paediatric Wards in Kenya—A Clinical Audit [PDF]

, 2017
Samuel Akech, Beatrice Rotich, Mercy Chepkirui, Philip Ayieko, Grace Irimu, Mike English, Samuel N’gar N’gar, Nick Aduro, Ivan Injira, Loice Mutai, Christine Manyasi, David Kimutai, Caren Emadau, Cecilia Mutiso, Celia Muturi, Charles Nzioki, Supa Tunje, Francis Kanyingi, Agnes Mithamo, Magdalene Kuria, Sam Otido, Anne Kamunya, Alice Kariuki, Grace Wachira, Peris Njiiri, Rachel Inginia, Melab Musabi, Barnabas Kigen, Sande Charo, Grace Akech, Lydia Thuranira, Morris Ogero, Thomas Julius, Boniface Makone, Mercy Chepkirui, Wycliffe Nyachiro, James Wafula   +36 more
openalex   +1 more source

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

Schwann Cell Synthesized Cholesterol Orchestrates Peripheral Nerve Regeneration via Structural and IGF1‐Dependent Signaling Mechanisms

Advanced Science, EarlyView.
This study reveals that Schwann cell FDFT1‐mediated cholesterol synthesis is essential for peripheral nerve regeneration via dual roles: as a structural component for myelin and as a metabolic signal that upregulates IGF1. IGF1 promotes axonal growth through paracrine action and enhances Schwann cell differentiation/ myelination via an intrinsic IGF1R ...
Shuyi Xu, Ye He, Ying Zou, Mengyao Zhao, Jiaqi Zhang, Yizhou Xu, Jiale Cai, Xiongbo Luo, Xinrui Ma, Saini Wu, Yuling Huang, Xianghai Wang, Jiasong Guo   +12 more
wiley   +1 more source

The role of serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in detecting acute kidney injury in preterm neonates exposed to nephrotoxic drugs. [PDF]

BMC Pediatr
Eldegwi M, Hassan S, Saadoun M, Ahmed H, Reyad H, Elnahal A.   +5 more
europepmc   +1 more source

Predictors of early motor trajectories from birth to 5 years in neonatal at‐risk and control children

, 2019
Nicole Baumann, James R. Tresilian, Kati Heinonen, Katri Räikkönen, Dieter Wolke   +4 more
openalex   +2 more sources

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Respiratory potentially pathogenic bacteria are associated with increased disease severity in neonates with respiratory syncytial virus infection. [PDF]

BMC Infect Dis
Yang X, Ding L, Ding X.
europepmc   +1 more source

Neonatal Diphtheria [PDF]

Archives of Disease in Childhood, 1953
openaire   +2 more sources

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

The Genetic Architecture of Congenital Heart Disease in Neonatal Intensive Care Unit Patients—The Experience of University Medical Centre, Ljubljana [PDF]

Ana Peterlin, Sara Bertok, Karin Writzl, Luca Lovrečić, Aleš Maver, Borut Peterlin, Maruša Debeljak, Gregor Nosan   +7 more
openalex   +1 more source