Results 131 to 140 of about 25,113 (217)

[Health surveillance after the Samarco dam disaster: evaluation of standards of care in chronic diseases and mental disorders (2008-2023)]. [PDF]

Cad Saude Publica
Rigoni GS, Sobral A, Santos JEMD, Périssé ARS.   +3 more
europepmc   +1 more source

Lewy Body Disease Across Aging: Clinical and Neuropathological Correlates in a Population Brain Bank

Movement Disorders, EarlyView.
Abstract Background Lewy body disease (LBD) is defined by neuronal α‐synuclein pathology, but how Braak‐staged LBD relates to mixed neuropathology and clinical manifestations within a single population‐based cohort remains incompletely characterized. This is especially relevant in cohorts enriched for younger individuals, which may better inform real ...
Vitor Ribeiro Paes, Felipe Luiz Pereira, Caroline Matos Silva, Filipe Oto Cunha de Moraes, Inês Liguori Padrão, Alberto Fernando Oliveira Justo, Roberta Diehl Rodriguez, Michel Satya Naslavsky, Renata Elaine Paraizo Leite, Carlos Augusto Gonçalves Pasqualucci, Mayana Zatz, Eduardo Ferriolli, Claudia Kimie Suemoto, Lea Tenenholz Grinberg   +13 more
wiley   +1 more source

Genome agnostic, multi-level non-oncogene addiction-based systems pharmacology for rescuing metastatic relapsed/refractory neoplasias. [PDF]

Front Pharmacol
Harrer DC, Lüke F, Pukrop T, Ghibelli L, Reichle A, Heudobler D.   +5 more
europepmc   +1 more source

TGF‐β Inhibition Attenuates Tau Accumulation and Neurodegeneration in Progressive Supranuclear Palsy Patient‐Derived Organoids

Movement Disorders, EarlyView.
Abstract Background Progressive supranuclear palsy (PSP) is a devastating 4‐repeat tauopathy with no approved disease‐modifying treatments. Recent evidence showed increased transforming growth factor‐β (TGF‐β) levels in PSP patient‐derived ventral midbrain organoids (vMOs) and serum neuronally derived exosomes. Objective This study investigated whether
Mariagrazia Talarico, Andrea Quattrone, Giorgia Lucia Benedetto, Raffaele Covello, Maurizio Martini, Valeria Zuccalà, Giovanni Cuda, Elvira Immacolata Parrotta, Aldo Quattrone   +8 more
wiley   +1 more source

Idiopathic Primary Chylopericardium. [PDF]

Arq Bras Cardiol
Ruffo CH, Rosa Filho AAM, Favaro GL, Hirose JSM, Lewinter RM, Melillo N, Silva LI, Anbar R, Coelho MM, Generoso G.   +9 more
europepmc   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

Obesity, EarlyView.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter, Julie Mount, J. Martin Gibson, Joanne Webb, Cheryl Marler, Catherine Reed, Mugdha Gore, Wenyu Ye, Elisa Gomez Valderas, John Wilding, Naveed Sattar, Melanie J. Davies, Kamlesh Khunti, Richard Haynes, Rachel L. Batterham   +14 more
wiley   +1 more source

Primary Tumor Location and Lymphatic Spread in Papillary Thyroid Carcinoma

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Papillary thyroid carcinoma (PTC) frequently metastasizes to cervical lymph nodes. Surgical planning is often based on the presumed central‐to‐lateral pattern of spread. The extent of central and lateral neck dissection remains controversial, with recommendations largely derived from small series. The study aimed to determine whether
Isabelle Fournier, Mark E. Zafereo, Sarah Hamidi, Erich M. Sturgis, Steven G. Waguespack, Michelle D. Williams, S. Mohsen Hosseini, Mimi I. Hu, Paul H. Graham, Victoria Banuchi, Neil D. Gross, Miriam N. Lango, Jennifer R. Wang, Maria E. Cabanillas, Naifa L. Busaidy, Ramona Dadu, Priyanka Iyer, Steven I. Sherman, Sachin K. Gupta, Ryan P. Goepfert, Elizabeth G. Grubbs, Michael Kwon, Salmaan Ahmed, Anastasios Maniakas   +23 more
wiley   +1 more source

Spatial Distribution of Patients in the Metropolitan Area of São Paulo Attending a Public Tertiary Cardiovascular Referral Hospital According to Diseases of the Circulatory, Respiratory, Endocrine, and Neoplastic Systems. [PDF]

Arq Bras Cardiol
Lederman C, Moraes SL, Lima ACP, Barroso LP, Morais LCC, Perdigão ML, Freitas RMV, Teixeira MP, Waldvogel BC, Gutierrez MA, Barrozo LV, Mansur AJ.   +11 more
europepmc   +1 more source

Pink Polypoid Papulo‐Vesicles on Labia Majora

JEADV Clinical Practice, EarlyView.
Maria Chiara Mercuri, Michela Tabanelli, Silvia Zago, Diego Abbenante   +3 more
wiley   +1 more source