Results 241 to 250 of about 160,978 (345)

Second part. [PDF]

Biomedica
Zea-Vera AF, Fernandes-Pineda M.
europepmc   +1 more source

A Combinatorial Effect of Immune Checkpoint Inhibitors and CD40 Agonistic Antibody in Murine Pancreatic Cancer Model

Cancer Science, EarlyView.
We established and extensively analyzed an organoid‐based mouse model that closely mimics human pancreatic ductal adenocarcinoma. Monotherapy with an immune checkpoint inhibitor cocktail or a CD40 agonist antibody showed minimal efficacy. However, combining both reagents produced a strong synergistic effect by enhancing anti‐tumor immunity.
Juri Ichikawa, Hiroshi Okuda, Kuniyuki Kawano, Shingo Kato, Shinya Sato, Ryo Kuroishikawa, Daisuke Kurotaki, Wataru Kawase, Haruka Yoshida, Yukihiko Hiroshima, Itaru Endo, Shin Maeda, Tomohiko Tamura   +12 more
wiley   +1 more source

Epidemiological profile of surgical treatment of lung cancer: retrospective analysis, Brazil, 2014-2023. [PDF]

Epidemiol Serv Saude
Alberti AM, Kieling L, Silva PBED, Azambuja FS, Godoy L, Concolatto FP, Lech GE, Stein AT.   +7 more
europepmc   +1 more source

TXI Raises Detection of Non-Neoplastic Polyps Without Improving Clinically Meaningful Neoplasia Endpoints [PDF]

Zhenkang Li, Huang Junpeng, Lang Xie
openalex   +1 more source

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

Cancer Science, EarlyView.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki, Keiko Shinjo, Tatsunori Nishimura, Yutaka Kondo   +3 more
wiley   +1 more source

Analysis of Mortality from Multiple Causes in Heart Failure Categorized by Ejection Fraction. [PDF]

Arq Bras Cardiol
Dutra GP, Gomes BFO, Silva TMBD, Peres LS, Rangel MANA, Petriz JLF, Carmo Junior PRD, Nascimento EM, Pereira BB, Oliveira GMM.   +9 more
europepmc   +1 more source

Lung metastases in low‐risk gestational trophoblastic neoplasia: a retrospective cohort study

, 2019
MM Frijstein, CAR Lok, NE van Trommel, MJ ten Kate‐Booij, LFAG Massuger, Erik van Werkhoven, D Short, Xianne Aguiar, R. Fisher, Baljeet Kaur, Naveed Sarwar, Neil J. Sebire, MJ Seckl   +12 more
openalex   +2 more sources

Single‐Cell and Multiomic Analysis Reveals Neutrophil Heterogeneity and Prognostic Value in Cervical Lesions

Cancer Science, EarlyView.
This study is the first to identify a novel neutrophil subpopulation, N4, that is closely associated with the progression of cervical cancer. Characterized by high PLAU expression and specific interactions with tumor cells, N4 neutrophils were shown to promote tumor growth and immune modulation.
Ze Wang, Liang Zhuang, Shiyi Liu, Canhui Cao, Shimin Chen, Nan Yu, Xiaoyuan Huang, Tao Zhang   +7 more
wiley   +1 more source

Post-discharge Mortality in Heart Failure: Insights from a Multiple-Cause Analysis. [PDF]

Arq Bras Cardiol
Guazzelli DL, Avila MS.
europepmc   +1 more source

Mixed Gonadal Dysgenesis: A Comprehensive Review of Clinical Spectrum, Diagnostic Strategies, and Management Approaches

Clinical Endocrinology, EarlyView.
ABSTRACT Background Mixed gonadal dysgenesis (MGD) is a rare form of differences in sex development (DSD) typically associated with 45,X/46,XY mosaicism. The phenotypic presentation of MGD varies from atypical genitalia to typical male or female appearances often associated with Turner stigmata.
Dinesh Giri, Sushil Yewale, Hannah Hickingbotham, Cara Williams, Mohamed Shalaby, Julie Alderson, Julie Park   +6 more
wiley   +1 more source