Results 61 to 70 of about 284,529 (384)

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source

Incidence and Control of Symptoms at the End of Life in Cancer Patients

Revista Finlay, 2021
Background: at the end of life, the patient with cancer conditions presents various physical, emotional and spiritual symptoms. Palliative medicine allows a continuous and comprehensive treatment for the diagnosis and control of symptoms.
Celita Mairely Celada Cifuentes, Javier García Gutiérrez, Sandra Pérez Palenzuela, Cecilia Navarrete Dávalos   +3 more
doaj  

Hemangioma cavernoso: relato de caso

Brazilian Neurosurgery, 2013
O hemangioma cavernoso é uma neoformação vascular benigna de origem congênita, caracterizando pela formação de grandes canais e espaços vasculares preenchidos com sangue. O caso relatado no estudo chama atenção não só devido à magnitude da tumoração e ao
Eduardo Queirós Miranda, José Edison da Silva Cavalcante, Zacarias Calil, Giordano Queirós Miranda   +3 more
doaj   +1 more source

Modeling human endothelial cell transformation in vascular neoplasias

Disease Models & Mechanisms, 2013
Endothelial cell (EC)-derived neoplasias range from benign hemangioma to aggressive metastatic angiosarcoma, which responds poorly to current treatments and has a very high mortality rate.
V. Wen, K. MacKenzie
semanticscholar   +1 more source

MTCH2 Deficiency Promotes E2F4/TFRC‐Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib

Advanced Science, EarlyView.
This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing, Jiangbo Chen, Hao Hao, Xiaowen Qiao, Xinying Yang, Kai Weng, Jie Chen, Lin Song, Tianqi Liu, Yifan Hou, Tongkun Song, Yumeng Ran, Bo Chen, Hong Yang, Wei Zhao, Zaozao Wang, Jiabo Di, Beihai Jiang, Xiangqian Su   +18 more
wiley   +1 more source

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Advanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu   +37 more
wiley   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

Casuística dos diagnósticos histopatológicos de cães e gatos atendidos no município de Natal, Rio Grande do Norte

Medicina Veterinária, 2023
Descrevem-se os diagnósticos histopatológicos de cães e gatos atendidos em Natal, Rio Grande do Norte, Brasil. Foram revisados os registros de biópsia de um laboratório de serviço patológico, dos quais se obtiveram informações sobre espécie, idade, sexo
Elizandra Teixeira Melo, Maria Luiza Sá de Lyra Frota, José Rodrigo Pontes dos Santos, Silvio Miguel Castillo Fonseca, Juliana Lucia Correia, Carla Manuela Morais Pinto, Anacleir Cruz de Oliveira, Telma de Sousa Lima   +7 more
doaj  

FEELINGS, RECEPTION AND HUMANIZATION IN PALLIATIVE CARE TO CHILDREN WITH LEUKEMIA

Revista de Pesquisa Cuidado é Fundamental Online, 2013
Objetivo: Compreender a visão da equipe multidisciplinar perante a criança portadora de leucemia, em cuidado paliativo. Métodos: O presente estudo é de abordagem qualitativa, delineado pelo método de estudo de caso.
Mayara Rosário Soares, Thaisa Gino Rodrigues, Danielle Moreira Nascimento, Marina Lira Santos Rosa, Selma Maria Fonseca Viegas, Patrícia Oliveira Salgado   +5 more
doaj   +1 more source

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu, Hongxia Cheng, Jiacheng Yin, Yuansheng Zheng, Haochun Shi, Binyang Pan, Ming Li, Mengnan Zhao, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Guoshu Bi, Weigang Guo, Lin Wang, Yiwei Huang   +14 more
wiley   +1 more source