Results 41 to 50 of about 1,559,633 (249)

In vivo and in vitro sensitivity of blastic plasmacytoid dendritic cell neoplasm to SL-401, an interleukin-3 receptor targeted biologic agent

Haematologica, 2015
Blastic plasmacytoid dendritic cell neoplasm is an aggressive malignancy derived from plasmacytoid dendritic cells. There is currently no accepted standard of care for treating this neoplasm, and therapeutic strategies have never been prospectively ...
Fanny Angelot-Delettre, A. Roggy, A. Frankel, B. Lamarthée, E. Seillès, S. Biichlé, B. Royer, E. Deconinck, E. Rowinsky, C. Brooks, V. Bardet, B. Bénet, H. Bennani, Zehaira Benseddik, A. Debliquis, D. Lusina, M. Roussel, F. Solly, M. Ticchioni, P. Saas, F. Garnache-Ottou   +20 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm

Mediators of Inflammation, 2015
Our understanding of inflammation's role in the pathogenesis of myeloproliferative neoplasm (MPN) is evolving. The impact of chronic inflammation, a characteristic feature of MPN, likely goes far beyond its role as a driver of constitutional symptoms. An
Angela G. Fleischman
semanticscholar   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Low-grade appendiceal mucinous neoplasm (LAMN) as a mimicker of perforated diverticulitis: a case report [PDF]

, 2022
Christopher Shean, Janaka Balasooriya, James Fergusson   +2 more
openalex   +1 more source

Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: an Italian multicenter study

Haematologica, 2013
The objective of this study was to evaluate the clinical features, prognostic factors, and efficacy of treatments in patients with blastic plasmacytoid dendritic cell neoplasm with a leukemic presentation at onset of the disease.
L. Pagano, C. Valentini, A. Pulsoni, S. Fisogni, P. Carluccio, F. Mannelli, M. Lunghi, G. Pica, F. Onida, C. Cattaneo, P. Piccaluga, E. di Bona, E. Todisco, P. Musto, A. Spadea, A. D’Arco, S. Pileri, G. Leone, S. Amadori, F. Facchetti   +19 more
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Prognostic factors in patients with Hürthle cell neoplasms of the thyroid [PDF]

, 2003
Luis Lopez‐Penabad, Alice C. Chiu, Ana O. Hoff, Pamela N. Schultz, Sonia Gaztambide, Nelson G. Ordóǹez, Steven I. Sherman   +6 more
openalex   +1 more source

772 MHC-I skewing in mutant calreticulin-positive myeloproliferative neoplasms is countered by heteroclitic peptide cancer vaccination [PDF]

, 2021
Mathieu Gigoux, Roberta Zappasodi, Joseph Park, Cansu Cimen Bozkus, Levi Mangarin, David Redmond, Svena Verma, Sara Schad, Mariam M. George, Divya Venkatesh, Arnab Ghosh, Zaki Molvi, Baransel Kamaz, Anna E. Marneth, William S. Duke, Matthew Leventhal, Max Jan, Vincent T. Ho, Gabriela Hobbs, Trine Alma Knudsen, Vibe Skov, Lasse Kjær, Thomas Stauffer Larsen, Dennis Lund Hansen, R. Coleman Lindsley, Hans Carl Hasselbalch, Jacob Handlos Grauslund, Mads Hald Andersen, Morten Orebo Holmström, Timothy A. Chan, Raajit K. Rampal, Omar Abdel‐Wahab, Nina Bhardwaj, Ann Mullally, Jedd D. Wolchok, Taha Merghoub   +35 more
openalex   +1 more source