Results 41 to 50 of about 1,272,281 (247)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Cutaneous CD4+/ CD56 hematodermic neoplasm

, 2010
CD4+/CD56+ hematodermic neoplasm, formerly known as blastic NK cell lymphoma, is a rare and aggressive neoplasm with a high incidence of cutaneous involvement, risk of leukemic dissemination and poor prognosis.
Kavala, Mukaddes, Ilkin Zindanci, Buyukbabani, Nesimi, Kocaturk, Emek, Melek Koc, Mukaddes Kavala, Zindanci, Ilkin, Koc, Melek, Emek Kocaturk, Nesimi Buyukbabani   +9 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Co-occurrence of myeloid neoplasm and plasma cell neoplasm

, 2022
Co-occurrence of myelodysplastic syndrome (MDS) and plasma cell neoplasm in patients with no history of chemo and/or radiotherapy is rarely reported. Herein, we report a case of a female in her seventieth decade of life who was referred to the hospital ...
Jum’ah, Husam, Husam Jumah, Salman Ayub, Ayub, Salman, Yan Wang, Yan Wang, Husam Jum’ah, Salman Ayub, Husam Jum’ah, Wang, Yan   +9 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Blastic plasmacytoid dendritic cell neoplasm: challenges and future prospects

, 2017
Amy M Trottier, Sonia Cerquozzi, Carolyn J Owen Division of Hematology and Hematological Malignancies, University of Calgary, Foothills Medical Centre, Calgary, AB, Canada Abstract: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare CD4+ CD56+
Trottier AM, Cerquozzi S, Owen CJ
core  

Demographic and clinical characteristics of admissions with myeloid neoplasm and lymphoid neoplasm.

, 2014
CVC: central venous catheterization. Data presented as number (%), mean ± SD, or median (interquartile range), as appropriate.Demographic and clinical characteristics of admissions with myeloid neoplasm and lymphoid neoplasm.
Yubin Xing (520421), Mingmei Du (520424), Hui Liu (33624), Jin Zhao (94790), Yunxi Liu (520427), Meng Li (79487), Jijiang Suo (520420)   +6 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-kB pathway inhibition.

, 2014
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare disease of controversial origin recently recognized as a neoplasm deriving from plasmacytoid dendritic cells (pDCs).
Pileri A. Jr, Gazzola A, Rossi M, Cerroni L, FACCHETTI, Fabio, Arpinati M, Santucci M, Fuligni F, for the AIRC 5xMille consortium ‘Genetics driven targeted management of lymphoid malignancies’, the Italian Registry on Blastic Plasmacytoid Dendritic Cell Neoplasm, Agostinelli C, Sapienza MR, GIBELLINI, Davide, Gibellini D, Laginestra MA, Mannu C, Maeda T, Croce CM, Tripodo C, Pileri SA, Righi S, Ulbar F, Melle F, Pagano L, Paulli M, Ricci F, Piccaluga PP, Facchetti F, Mancini M, Pimpinelli N   +29 more
core   +2 more sources