Interobserver variation among cytopathologists in the evaluation of oncocytic cell-predominant thyroid FNA cytology: A validation study of 173 cases with surgical follow-up and correlation with molecular testing. [PDF]
Elsheikh TM +5 more
europepmc +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Loss of Twist impairs tentacle development and induces epithelial neoplasia in the sea anemone Nematostella vectensis. [PDF]
Murguia PF +6 more
europepmc +1 more source
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Transformation From Oxyntic Gland Neoplasm Into Advanced Gastric Cancer via <i>TP53</i> Mutation: A First Case Report. [PDF]
Komatsu A +8 more
europepmc +1 more source
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Exploratory Analysis of Quality Indicators for Esophagogastroduodenoscopy During Surveillance Following Gastric Endoscopic Scubmucosal Dissection. [PDF]
Uozumi T +7 more
europepmc +1 more source
CEACAM1 participation in breast cancer progression
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Trends and disparities in neoplasm-related mortality with death-certificate-documented protein-energy malnutrition in the United States, 1999-2024: a CDC WONDER multiple cause of death study. [PDF]
Gan Q, Xia K, Yang X.
europepmc +1 more source

