Results 191 to 200 of about 1,419,483 (292)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Stage IV SMARCA4-Deficient Undifferentiated Malignant Neoplasm With Primary Cutaneous Origin and Early Distant Metastases. [PDF]

Case Rep Dermatol Med
Smaha KM, Willett M, Kent DE.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Incidental giant renal schwannoma misdiagnosed as angiomyolipoma and low-grade spindle cell neoplasm: A case report

Anahita Ansari Djafari, Sina Samenezhad, Mohammad Seifipoor, Dorna Rafighi   +3 more
openalex   +1 more source

Therapy-related myeloid neoplasms for the treatment of breast cancer: systematic review

, 2020
Alexandre Gustavo Apa
openalex   +1 more source

Risk of malignancy of cytologic categories and post-biopsy clinical management of renal oncocytic neoplasms. [PDF]

Cancer Cytopathol
Lin X.
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

THE ATAXIA-TELANGIECTASIA MUTATED (ATM) GENE PLAYS A PIVOTAL ROLE IN THE REPAIR OF DNA IN CASES OF MYELODYSPLASTIC NEOPLASM

JVC Goes, LR Sampaio, RTG Oliveira, DP Borges, RDB Dias, César Erineudo Tavares de Araújo, PRC Passos, HLR Junior, SMM Magalhães, RF Pinheiro   +9 more
openalex   +1 more source

Fallopian tube lavage sampling towards early detection of pre-invasive ovarian cancer. [PDF]

Clin Transl Med
Seaton M, Harbach S, Oke J, Walker TDJ, Dalton-O'Reilly J, Selley J, Brison DR, Bolton J, Meyer S, Knight D, Edmondson RJ, Schmidt CK.   +11 more
europepmc   +1 more source