Results 211 to 220 of about 1,700,231 (391)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Germline rare variants in cancer susceptibility genes and subsequent neoplasm risk after childhood cancer. [PDF]

J Natl Cancer Inst
Zamani SA, Karyadi DM, Hartley SW, Gibson TM, Sampson JN, Kraft P, Chanock SJ, Morton LM.   +7 more
europepmc   +1 more source

Clinical-laboratory, therapeutic and survival profile of patients with low-risk Myelodysplastic Neoplasm in southern Brazil [PDF]

C. Weber, Tahiane de Brum Soares
openalex   +1 more source

Treatment-free remission in FIP1L1-PDGFRA–positive myeloid/lymphoid neoplasms with eosinophilia after imatinib discontinuation [PDF]

, 2020
Georgia Metzgeroth, Juliana Schwaab, Nicole Naumann, Mohamad Jawhar, Torsten Haferlach, Alice Fabarius, Andreas Hochhaus, Wolf‐Karsten Hofmann, Nicholas C.P. Cross, Andreas Reiter   +9 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Second Primary Cancer After Bladder Cancer: A Comprehensive Analysis of a National Cancer Registry. [PDF]

Cancer Med
Buchler T, Pehalova Kusova L, Pirshtuk A, Muzik J, Babjuk M, Dusek L.   +5 more
europepmc   +1 more source

Clinical Course of Patients With Incidental Finding of 20q- in the Bone Marrow Without a Myeloid Neoplasm [PDF]

, 2015
Majd Jawad, Min Shi, C. Christopher Hook, Ronald S. Go   +3 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Examination of Appendiceal Neoplasms-A Retrospective, Single-Centre, Cohort Study. [PDF]

Cancers (Basel)
Csonka B, Lantos T, Sejben A.
europepmc   +1 more source

Healthcare Resource Utilization and Treatment Costs for Blastic Plasmacytoid Dendritic Cell Neoplasm: A PETHEMA Study [PDF]

Antonio Solana‐Altabella, Irene Navarro-Vicente, Eduardo Rodríguez‐Arbolí, Víctor Noriega, Josefina Serrano, Teresa Bernal, Vicente Carrasco-Baraja, Raimundo García‐Boyero, C Olivier, Lorenzo Algarra, Eduardo López Briz, Armando V. Mena-Durán, Jackeline Solano-Tovar, Carmen Botella-Prieto, Sara Sánchez-Sánchez, Juan Bergua, Pilar Lloret Madrid, Mario Rodenas-Rovira, Blanca Boluda, Isabel Cano‐Ferri, Evelyn Acuña‐Cruz, Rebeca Rodríguez‐Veiga, Laura Torres-Miñana, María Centelles-Oria, José Luís Poveda, David Martínez‐Cuadrón, Pau Montesinos   +26 more
openalex   +1 more source