Results 281 to 290 of about 704,490 (345)

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

Artificial intelligence-aided optical biopsy improves the diagnosis of esophageal squamous neoplasm. [PDF]

World J Gastroenterol
Ma T, Liu GQ, Guo J, Ji R, Shao XJ, Li YQ, Li Z, Zuo XL.   +7 more
europepmc   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

High-grade eosinophilic renal tumor/eosinophilic vacuolar renal tumor: a case report and literature review. [PDF]

BMC Urol
Ou Y, Ren S, Zhou F, Chen Z, Lv Q, Nie Y, Wang D, Fan S.   +7 more
europepmc   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Descriptive report of complex cystic renal mass fluid cytology: a cross-sectional analysis. [PDF]

Transl Androl Urol
Jefferson FA, Cohen TD, Zheng G, Gupta S, Lee MS, Foss HE, Schneider A, Straubmuller V, Khanna A, Chow GK, Potretzke TA, Potretzke AM.   +11 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Pancreatic solid pseudopapillary neoplasm, rare presentation in pediatric age group: two case reports. [PDF]

Front Oncol
Alshawwa K, Njoum Y, Abdul-Hafez HA, Bannoura S, Abukeshek T, Ashhab H, Abu-Zaydeh O.   +6 more
europepmc   +1 more source

Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding

FEBS Open Bio, EarlyView.
The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla, Faiza Abbas, Luigia Rossi, Mauro Magnani, Sara Biagiotti   +4 more
wiley   +1 more source

Changes in the Percentage of Patients Treated for Cancer Before and After the SARS-CoV-2 Epidemic: A Retrospective Observational Study. [PDF]

Juntendo Iji Zasshi
Maehara Y, Fujibayashi K, Kuwatsuru R, Daida H, Aoki S.   +4 more
europepmc   +1 more source