Results 41 to 50 of about 1,272,186 (267)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Co-occurrence of myeloid neoplasm and plasma cell neoplasm

, 2022
Co-occurrence of myelodysplastic syndrome (MDS) and plasma cell neoplasm in patients with no history of chemo and/or radiotherapy is rarely reported. Herein, we report a case of a female in her seventieth decade of life who was referred to the hospital ...
Jum’ah, Husam, Husam Jumah, Salman Ayub, Ayub, Salman, Yan Wang, Yan Wang, Husam Jum’ah, Salman Ayub, Husam Jum’ah, Wang, Yan   +9 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Blastic plasmacytoid dendritic cell neoplasm: challenges and future prospects

, 2017
Amy M Trottier, Sonia Cerquozzi, Carolyn J Owen Division of Hematology and Hematological Malignancies, University of Calgary, Foothills Medical Centre, Calgary, AB, Canada Abstract: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare CD4+ CD56+
Trottier AM, Cerquozzi S, Owen CJ
core  

Demographic and clinical characteristics of admissions with myeloid neoplasm and lymphoid neoplasm.

, 2014
CVC: central venous catheterization. Data presented as number (%), mean ± SD, or median (interquartile range), as appropriate.Demographic and clinical characteristics of admissions with myeloid neoplasm and lymphoid neoplasm.
Yubin Xing (520421), Mingmei Du (520424), Hui Liu (33624), Jin Zhao (94790), Yunxi Liu (520427), Meng Li (79487), Jijiang Suo (520420)   +6 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-kB pathway inhibition.

, 2014
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare disease of controversial origin recently recognized as a neoplasm deriving from plasmacytoid dendritic cells (pDCs).
Pileri A. Jr, Gazzola A, Rossi M, Cerroni L, FACCHETTI, Fabio, Arpinati M, Santucci M, Fuligni F, for the AIRC 5xMille consortium ‘Genetics driven targeted management of lymphoid malignancies’, the Italian Registry on Blastic Plasmacytoid Dendritic Cell Neoplasm, Agostinelli C, Sapienza MR, GIBELLINI, Davide, Gibellini D, Laginestra MA, Mannu C, Maeda T, Croce CM, Tripodo C, Pileri SA, Righi S, Ulbar F, Melle F, Pagano L, Paulli M, Ricci F, Piccaluga PP, Facchetti F, Mancini M, Pimpinelli N   +29 more
core   +2 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Atypical fibroxanthoma arising in a tracheostomy scar: A rare cicatricial neoplasm

, 2019
Dear Editor, Atypical fibroxanthoma (AFX) is a cutaneous neoplasm that classically occurs in heavily sun‐damaged skin on the head and neck of elderly patients.1 We report the case of a 70‐year‐old man who presented with a 1‐year history of a slowly ...
Byth, Lachlan A, Lachlan A Byth, Strutton, Geoffrey M, Geoffrey M Strutton   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source