Human disordered charged biased proteins: from the proteome to the druggome [PDF]
Network BiologyThe human disordered charged biased proteins (HDCBPs) are involved in complex diseases. The HDCBP-disease network constructed in our earlier showed that HDCBPs share many diseases. Therefore, they are attractive therapeutic targets for drug discovery. In
Mouna Choura
doaj
Loss of O6‐Methylguanine‐DNA Methyltransferase Protein Expression by Immunohistochemistry Is Associated With Response to Capecitabine and Temozolomide in Neuroendocrine Neoplasms [PDF]
Mark G. Evans +7 more
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A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Discover OncologyPurpose Ameloblastoma (AM), a frequently encountered odontogenic epithelial neoplasm, demonstrates complex molecular pathogenesis involving dysregulation of cellular signaling networks.
Baoyinbatu Gabiyatu +7 more
doaj +1 more source
Expression of Lysosome-Associated Membrane Proteins in Human Colorectal Neoplasms and Inflammatory Diseases [PDF]
, 2001 Koh Furuta +8 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome [PDF]
, 2014 Arjen H.G. Cleven +9 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Exploring the Enigma: The Role of the Epithelial Protein Lost in Neoplasm in Normal Physiology and Cancer Pathogenesis [PDF]
Emma Lindell, Xiaonan Zhang
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