Results 161 to 170 of about 494,128 (290)

Differential expression of serine and glycine metabolism-related proteins between follicular neoplasm and Hürthle cell neoplasm.

International journal of clinical and experimental pathology
The aim of the study was to investigate the expression of serine/glycine-related proteins in Hürthle cell neoplasm (HCN) and follicular neoplasm (FN) and to explore its associated implications. Tissue microarrays were constructed with 265 cases of FN (follicular carcinoma [FC]: 112 and follicular adenoma [FA]: 153) and 107 cases of HCN (Hürthle cell ...
Hye Min, Kim, Eun-Sol, Kim, Ja Seung, Koo   +2 more
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Evaluating the causal effects of circulating plasma proteins on the risk of malignant neoplasms of bone and articular cartilage. [PDF]

J Int Med Res
Wang Y, Zhou R, Wu Z, Lv Z.
europepmc   +1 more source

MOESM5 of Quantitative proteomic analysis of pancreatic cyst fluid proteins associated with malignancy in intraductal papillary mucinous neoplasms

, 2018
Misol Do, Dohyun Han, Joseph Wang, Hyunsoo Kim, Wooil Kwon, Youngmin Han, Jin‐Young Jang, Youngsoo Kim   +7 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Marrow Microenvironmental Pathobiology and Therapeutic Opportunities for TP53-Mutated Myelodysplastic Syndrome/Acute Myeloid Leukemia. [PDF]

Cancers (Basel)
Hunter CJ, Im AP, Shallis RM.
europepmc   +1 more source

BCL-6 Protein Expression in Human Peripheral T-Cell Neoplasms Is Restricted to CD30+ Anaplastic Large-Cell Lymphomas [PDF]

, 1997
Antonino Carbone, Annunziata Gloghini, Gianluca Gaïdano, Riccardo Dalla‐Favera, Brunangelo Falini   +4 more
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A protocol for using human genetic data to identify circulating protein level changes that are the causal consequence of cancer processes. [PDF]

PLoS One
Hobson LM, Martin RM, Smith-Byrne K, Davey Smith G, Hemani G, Gilbody JH, Yarmolinsky J, Bailey SER, Goudswaard LJ, Haycock PC.   +9 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source