Results 181 to 190 of about 232,408 (333)

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

open access: yesAdvanced Science, EarlyView.
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan   +19 more
wiley   +1 more source

A New Relevant Integrated Radiologic and Surgical Classification Scheme for Giant Cell Tumors of Bones. [PDF]

open access: yesJ Am Acad Orthop Surg Glob Res Rev
Chang YC   +7 more
europepmc   +1 more source

Nanoscale Metal‐Organic Framework‐Based Self‐Monitoring Oxygen Economizer and ROS Amplifier for Enhanced Radiotherapy‐Radiodynamic Therapy

open access: yesAdvanced Science, EarlyView.
A Fe (III)–Pt (II) porphyrin framework‐based radiosensitizer (FPTM‐LP) is constructed to serve as an oxygen economizer, hypoxia self‐monitoring device, and reactive oxygen species (ROS) amplifier. The glutathione (GSH)/pH‐responsive release of lonidamine achieves oxygen‐economization to combat hypoxia‐induced radioresistance guided by near infrared ...
Shiye Du   +9 more
wiley   +1 more source

Recurrence of laryngeal squamous cell carcinoma in patients undergoing organ preservation therapy: Are there symptoms associated with recurrence? [PDF]

open access: yesBraz J Otorhinolaryngol
Lisboa SR   +7 more
europepmc   +1 more source

DNase I‐Mediated Chemotactic Nanoparticles for NETs Targeting and Microenvironment Remodeling Treatment of Acute Ischemic Stroke

open access: yesAdvanced Science, EarlyView.
The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang   +7 more
wiley   +1 more source

Functional Outcomes of Surgical Treatment for Giant Cell Tumors around the Knee. [PDF]

open access: yesJ Orthop Case Rep
Yadav SK   +4 more
europepmc   +1 more source

Solitary lymph node metastasis without local recurrence of primary chordoma

open access: yesEuropean spine journal, 2009
J. Sopta   +4 more
semanticscholar   +1 more source

Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

open access: yesAdvanced Science, EarlyView.
γGC deficiency in ulcerative colitis drives macrophage ferroptosis‐mediated inflammation. Claw‐engaged microparticles armed with γGC (γGC‐MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake. On the cover, Monkey King (Macrophages) was bound by the Immortal‐Binding Rope and subsequently sealed beneath the Five‐Fingered ...
Rong Wang   +10 more
wiley   +1 more source

Characteristics and Outcomes of Patients Who Underwent Curative Resection for Colorectal Cancer Local Recurrence. [PDF]

open access: yesCancer Diagn Progn
Maruyama K   +13 more
europepmc   +1 more source

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