Results 201 to 210 of about 319,917 (352)

Targeting the Notch1‐YY1‐ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8+ T‐Cell‐Driven Cancer Cell Pyroptosis

Advanced Science, EarlyView.
In hepatocellular carcinoma (HCC), aberrantly activated Notch1 signaling induces its target gene YY1, which impairs immunotherapy efficacy by suppressing tumor cell‐ICAM1‐driven T cell activation and the mediated pyroptosis of T cells against tumor cells.
Ke Zhu, Fa‐Peng Zhang, Chao Qin, Zhi‐Xiao Song, Cai‐Ni Yang, Shu‐Sheng Lin, Xian‐Huan Yu, Wen‐Rui Wu, Chao‐Qun Liu, Chao Liu, Lei‐Bo Xu   +10 more
wiley   +1 more source

Paraneoplastic Pemphigus in a Patient With Relapsed Breast Cancer: An Uncommon Presentation. [PDF]

Cureus
Salgado C, Cabo I, Fontinha G, Almeida R, Mendes Abreu J.   +4 more
europepmc   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

LMNA-NTRK1-rearranged spindle cell neoplasm with multiple relapses: a case report and literature review. [PDF]

Front Med (Lausanne)
Zhu Y, Wang Z, Xi H, Lu W, Sun M, Lin X.
europepmc   +1 more source

Argon plasma coagulation therapy after submucosal injection of normal saline solution for local recurrence of large nonampullary duodenal neoplasm

VideoGIE, 2016
Tomoyuki Hayashi, MD, Miyabi Miura, MD, Hajime Takatori, MD, PhD, Kazuya Kitamura, MD, PhD, Tatsuya Yamashita, MD, PhD, Shuichi Kaneko, MD, PhD   +5 more
openaire   +3 more sources

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Surgical resection of a primary cardiac angiosarcoma and reconstruction of involved right atrium. [PDF]

J Surg Case Rep
Xie J, Mai P, Wu Y, Wang X.
europepmc   +1 more source

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Carnoy's Solution for the Management of a Pediatric Patient with Adenomatoid Odontogenic Tumor: A Case Report with 2-year Follow-up. [PDF]

Int J Clin Pediatr Dent
Priya K, Shetty YR, Saha S, Kumar N, Nair MR.   +4 more
europepmc   +1 more source

A Case of Local Recurrence of Low-grade Appendiceal Mucinous Neoplasm

Nihon Daicho Komonbyo Gakkai Zasshi
Kiyoshi Wakao, Yuichiro Yoshioka, Ryutaro Kobayashi, Masahiko Fujino   +3 more
openaire   +1 more source