Results 121 to 130 of about 35,449 (253)

Clinical Validation of a QSP Model for ISB 2001, a Trispecific T Cell Engager to Support Optimal FIH Study Design in RRMM Patients

Clinical Pharmacology &Therapeutics, EarlyView.
ISB 2001 is a trispecific antibody that binds to two tumor‐associated antigens (TAA), CD38 and BCMA, and crosslinks to CD3 on T cells resulting in T cell‐mediated cytotoxicity of tumor cells expressing these TAAs. ISB 2001 is currently being tested in relapsed and/or refractory multiple myeloma (RRMM) patients in the first‐in‐human (FIH) TRIgnite‐1 ...
Vinu Chandralayam Ayyappa Menon, Tomomi Matsuura, Beata Holkova, Girish S. Gudi, Adam Drake, Maria Pihlgren, Piet H. van der Graaf, Sunitha GN, Andrew Garton, Mario Perro, Cyril Konto, Lida Pacaud   +11 more
wiley   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

The small molecule simufilam dose‐dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex

Epilepsia, EarlyView.
Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley, Md. Monirul Islam, Dean J. Aguiar, Zoë Fuchs, Mackenzie Catron, Stephen Morairty, Ying Yuan, Radleigh Santos, Jingguo Hou, Annelies de Kater, George B. Thornton, Angelique Bordey   +11 more
wiley   +1 more source

Spontaneous regression of equine sarcoids is an exceptional event

Equine Veterinary Journal, EarlyView.
Abstract Sarcoids are benign, yet locally aggressive skin tumours that commonly affect horses and other equid species. The lesions are induced by bovine papillomavirus types 1, 2, and probably 13 in conjunction with other factors including trauma and a genetic predisposition.
Sabine Brandt
wiley   +1 more source

Summary of the discussion on mammary carcinogenesis in the rat [PDF]

, 1982
Broerse, J. J., Gerber, G. B., Kellerer, Albrecht M.   +2 more
core   +1 more source

Brain–Computer Interfaces: The Dawn of a New Era in Disease Treatment

Exploration, EarlyView.
This study investigates the potential of brain–computer interface (BCI) technology in treating neuropsychiatric disorders, such as movement and communication barriers. Our review examines the history, signal paradigms, and diverse applications of BCI while also discussing ongoing research into novel materials and emerging technologies that offer ...
Yuqi Feng, Wangzheqi Zhang, Jun Chen, Huang Wu, Lei Wu, Yanhao Qiu, Xiaoming Deng, Chenglong Zhu, Yisheng Chen, Zhijie Zhao, Changli Wang, Xiaomin Zhang   +11 more
wiley   +1 more source

Postoperative and Functional Outcomes of Oropharyngectomy in Irradiated Neck for Recurrent or Metachronous Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Objective To evaluate predictors of postoperative and functional outcomes following salvage oropharyngectomy. Methods In this single‐center retrospective study, we included all patients who underwent an oropharyngectomy in an irradiated neck for recurrent or metachronous cancer between 2014 and 2023. Results We included 94 patients.
Jade Saykaly, Agnès Dupret‐Bories, Sébastien Vergez, Virginie Woisard, Benjamin Vairel, Jérôme Sarini, Ana Cavillon, Emilien Chabrillac   +7 more
wiley   +1 more source

Spontaneous Complete Regression of Aleukaemic Cutaneous Myeloid Sarcoma without Progression to Leukaemia Over a Long-term Follow-up Period

Acta Dermato-Venereologica
Hiromi Higaki-Mori, Nanako Yamada, Kanae Ozaki, Midori Filiz Nishimura, Yuichi Yoshida   +4 more
doaj   +1 more source

Pattern of Progression of Oral Potentially Malignant Disorders From Real‐World Data: A 24‐Year Study

Head &Neck, EarlyView.
ABSTRACT Background Oral potentially malignant disorder (OPMD) prognostication is limited by uncertainty of which lesions will progress and the aggressiveness of lesion progression. We defined patterns and kinetics of progression in a large cohort of OPMD subjected to serial clinical and histologic examinations. Methods This 24‐year study evaluated the
Subin Surendran, Sumsum P. Sunny, Preethi M. Chathoth, William J. Magner, S. Lynn Sigurdson, Mihai Merzianu, Norbert Sule, Anurag K. Singh, Kimberly E. Wooten, Ryan P. McSpadden, Vishal Gupta, Amritha Suresh, Ashok Z. Samuel, Rohit Bhargava, Praveen N. Birur, Wesley L. Hicks Jr, Moni Abraham Kuriakose   +16 more
wiley   +1 more source

Regressive Neuroblastoma: Widely Accepted, Underreported Histology. [PDF]

Clin Case Rep
Membrez T, Wilde JCH, Sanchez O, Papangelopoulou D, Gumy-Pause F, Rougemont AL.   +5 more
europepmc   +1 more source