Results 151 to 160 of about 35,449 (253)

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Spontaneous regression of metastatic disease after palliative debulking surgery for heavily pre-treated extraskeletal myxoid chondrosarcoma: A case report. [PDF]

Rare Tumors
Carroll HK, Keogh A, Barry S, Fabre A, O'Toole G, Crown J, O'Mahony D, Feeley K, Muneer A, Bambury RM.   +9 more
europepmc   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Spontaneous Regression in Pancreatic Neuroendocrine Tumor. [PDF]

Intern Med
Bamba M, Yamauchi Y, Matsumura T.
europepmc   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

Differences in Histopathology and Local Immune Response in Steady and Progressive Natural Transmissible Venereal Tumors in Mexican Dogs. [PDF]

Animals (Basel)
Martínez-Ramos IZ, Pérez-Maroto D, García-Álvarez N, Barroso P, García Balbuena A, Núñez-Martínez G, Bottini Luzardo MB, García Marín JF, Balseiro A.   +8 more
europepmc   +1 more source

The use of activated carbon derived from spent coffee grounds as a reusable, sustainable, and effective solution for the removal of butylparaben from water

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Parabens, including butylparaben (BP), are widely used as antimicrobial preservatives in food, cosmetics, and pharmaceuticals, yet are poorly removed by conventional water treatment processes and pose potential risks to aquatic life and human health.
Lorena Maihury Santos Tsubouchi, Diane Scapin, Gideã Taques Tractz, Flávia Aparecida Reitz Cardoso, Lúcio Cardozo‐Filho, Alessandro Francisco Martins, Diógenes Vedoy, Ana Paula Peron, Osvaldo Valarini Junior   +8 more
wiley   +1 more source

Spontaneous Regression (SR) of Male Breast Cancer (MBC): A Rare Case Highlighting Diagnostic Pitfalls and Management Caution. [PDF]

Case Rep Surg
Tay JC, Sia WT, Md Yusof N, Thee LJ.
europepmc   +1 more source

Age‐related local versus systemic early phase wound healing dynamics following free gingival graft harvest

Journal of Periodontology, EarlyView.
Abstract Background Free palatal gingival grafts (FGG) are commonly harvested during mucogingival procedures. The present study investigates age‐related local and systemic early secondary wound healing outcomes, following FGG harvest in a rat model. Methods A 4.2 mm diameter defect was created in the palate of 24 younger (2 m) and 24 older (6 m) Wistar
Maayan Atzmon‐Shavit, Marilena Vered, Michael Saminsky, Liat Chaushu   +3 more
wiley   +1 more source

Occult Thyroid Carcinoma Localized to Three Cervical Lymph Nodes Without Primary Origin in the Thyroid Gland: A Case Report. [PDF]

Case Rep Endocrinol
Murayama D, Nishida Y, Hishikawa S, Hirano R, Hashizume T, Azuhata K, Shimojo H, Ito N, Mishima O.   +8 more
europepmc   +1 more source