Results 81 to 90 of about 3,998,793 (310)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Road traffic pollution and childhood leukemia: a nationwide case-control study in Italy [PDF]

, 2016
Background The association of childhood leukemia with traffic pollution was considered in a number of studies from 1989 onwards, with results not entirely consistent and little information regarding subtypes.
Alberto Salvan, Alessandra Benvenuti, Alessandra Greco Veneto, Alessandra Ranucci, Alessandra Ranucci, Alessandro Polichetti, Alessandro Pulsoni, Andrea Farioli, Andrea Pession, Carmelo Rizzari, Chiara Badaloni, Claudia Galassi, Corrado Magnani, Corrado Magnani, Cristina Nuccetelli, Daniela Ferrante, Daniela Ferrante, Daniele Monetti, Domenico Franco Merlo, Domenico Franco Merlo, Egidio Celentano, Egidio Celentano, Erni Guarino, Francesco Bochicchio, Francesco Forastiere, Francesco Forastiere, Franco Locatelli, Franco Pannelli, Gabriella Bernini, Gian Luca DeSalvo, Gigliola de Nichilo, Gino Schilirò, Giorgio Assennato, Giorgio Assennato, Giulia Cesaroni, Giuseppe Masera, Giuseppe Sampietro, Lia Lidia Luzzatto, Liliana Minelli, Liliana Minelli, Lorenzo Gafà, Lucia Miligi, Lucia Miligi, Luigi Bisanti, Luigi Bisanti, Manuela Chiavarini, Maria Valeria Torregrossa, Maria Valeria Torregrossa, Marina Cuttini, Marina Cuttini, Maurizio Aricò, Paola Michelozzi, Paola Michelozzi, Paola Mosciatti, Paola Mosciatti, Paola Zambon, Paola Zambon, Pia Massaglia, Pierfranco Biddau, Pierluigi Cocco, Pierluigi Cocco, Riccardo Haupt, Riccardo Haupt, Roberto Rondelli, Roberto Rondelli, Roberto Targhetta, Rosaria Maria Valenti, Santina Cannizzaro, Santina Cannizzaro, Serena Risica, Stefania Varotto, Stefano Mattioli, Stefano Mattioli, Stefano Parodi, Susanna Lagorio, Susanna Lagorio, Ursula Kirchmayer, Veronica Casotto, Vincenzo Poggi, Vittorio Bocchini   +79 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The impact of high grade glial neoplasms on human cortical electrophysiology [PDF]

, 2017
ObjectiveThe brain's functional architecture of interconnected network-related oscillatory patterns in discrete cortical regions has been well established with functional magnetic resonance imaging (fMRI) studies or direct cortical electrophysiology from
Bandt, S. Kathleen, Breshears, Jonathan D, Bundy, David T, Hacker, Carl D, Leuthardt, Eric C, Pahwa, Mrinal, Roland, Jarod L, Sharma, Mohit, Shimony, Joshua S   +8 more
core   +3 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Only in the Heat of the Moment? A Study of the Relationship between Weather and Mortality in Germany [PDF]

In this study we analyze the relationship between heat events and mortality in Germany. The main research questions are: Does heat lead to rising mortality and if yes, are the effects persistent or compensated for in the near future?
Karlsson, Martin, Schmitt, Maike
core  

Improving Palliative Care with Deep Learning

, 2017
Improving the quality of end-of-life care for hospitalized patients is a priority for healthcare organizations. Studies have shown that physicians tend to over-estimate prognoses, which in combination with treatment inertia results in a mismatch between ...
Avati, Anand, Downing, Lance, Harman, Stephanie, Jung, Kenneth, Ng, Andrew, Shah, Nigam H.   +5 more
core   +1 more source

Association of Vitamin D3 Level with Breast Cancer Risk and Prognosis in African-American and Hispanic Women. [PDF]

, 2017
Background: This study investigated the association of vitamin D3 levels with breast cancer risk and progression in African-Americans and Hispanics. Methods: A total of 237 African-American (Cases = 119, Control = 118) and 423 Hispanic women (Cases = 124,
Chlebowski, Rowan, Clayton, Sheilah, Sarkissyan, Marianna, Vadgama, Jaydutt V, Wu, Yanyuan   +4 more
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source