Results 171 to 180 of about 676,711 (374)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Survival of patients with mucosal melanoma in Cali, Colombia: a retrospective cohort study

BMC Cancer
Background Mucosa melanoma is a rare condition with aggressive behavior and a less favorable prognosis compared to cutaneous melanoma. The objective of this study was to estimate the overall survival and clinical outcomes of patients diagnosed with ...
Ana M. García, Luis G. Parra-Lara, Diana M. Mendoza-Urbano, Juan C. Bravo, Ángela Zambrano Harvey   +4 more
doaj   +1 more source

Tumour Node Metastasis Staging as Prognostic Indicator for Surgical Decision-making Tool in Canine Mammary and Superficial Neoplasms: A Survival Analysis Study [PDF]

, 2022
Sudheesh S. Nair, M.K. Narayanan, Anoop Sainulabdeen, B. Dhanush Krishna, Usha Narayanapillai, K.D. John Martin   +5 more
openalex   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

TNM Staging of Neoplasms of the Endocrine Pancreas: Results From a Large International Cohort Study [PDF]

, 2012
Guido Rindi, Massimo Falconi, Catherine Klersy, Luca Albarello, Letizia Boninsegna, Markus W. Büchler, C. Capella, Martyn Caplin, Anne Couvelard, Claudio Doglioni, Gianfranco Delle Fave, L. Fischer, Giuseppe Fusai, Wouter W. de Herder, Henning Jann, Paul Komminoth, Ronald R. de Krijger, Stefano La Rosa, Tu Vinh Luong, Ulrich F. Pape, Aurel Perren, Philippe Ruszniewski, Aldo Scarpa, Anja Schmitt, Enrico Solcia, Bertram Wiedenmann   +25 more
openalex   +1 more source

Structured Reporting of Computed Tomography in the Staging of Neuroendocrine Neoplasms: A Delphi Consensus Proposal [PDF]

, 2021
Vincenza Granata, Francesca Coppola, Roberta Grassi, Roberta Fusco, Salvatore Tafuto, Francesco Izzo, Alfonso Reginelli, Nicola Maggialetti, Duccio Buccicardi, Barbara Frittoli, Marco Rengo, Chandra Bortolotto, Roberto Prost, G V Lacasella, Marco Montella, Eleonora Ciaghi, Francesco Bellifemine, Federica De Muzio, Ginevra Danti, Giulia Grazzini, Massimo De Filippo, Salvatore Cappabianca, Carmelo Barresi, Franco Iafrate, Luca Pio Stoppino, Andrea Laghi, Roberto Grassi, Luca Brunese, Emanuele Neri, Vittorio Miele, Lorenzo Faggioni   +30 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Use of T2 signal intensity of cerebellar neoplasms in pediatric patients to guide preoperative staging of the neuraxis

, 2011
Jonathan A. Forbes, Lola B. Chambless, Jason G. Smith, Curtis A. Wushensky, Richard L. Lebow, JoAnn Alvarez, Matthew M. Pearson   +6 more
openalex   +2 more sources