Results 211 to 220 of about 76,990 (339)

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Different Presentations and Different Treatment Options in Blastic Plasmacytoid Dendritic Cell Neoplasms: A Case Series. [PDF]

Int J Hematol Oncol Stem Cell Res
Cengiz E, Aydin MS, Gunes AK, Ceran F, Dagdas S, Ozet G.   +5 more
europepmc   +1 more source

Orthotopic liver transplantation [PDF]

, 1980
Starzl, TE
core  

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

Therapeutic Challenges and Emerging Strategies for <i>T674I</i> and <i>PTPN11</i> Mutations in a <i>FIP1L1-PDGFRA</i>-Positive Myeloproliferative Neoplasm: A Case Report. [PDF]

Life (Basel)
Özkan SG, Kimiaei A, Safaei S, Karkucak M, Yenerel MN, Öztürkmen AY, Alp B, Özkan HA.   +7 more
europepmc   +1 more source

MCV/Q, Medical College of Virginia Quarterly, Vol. 14 No. 2 [PDF]

, 1978

core   +1 more source

Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

Advanced Science, EarlyView.
This review focuses on the immunomodulatory mechanisms of molecular hydrogen, the recent detection methods, and the classification advanced molecular hydrogen delivery materials. It provides a detailed description of their applications in areas such as arthritis, chronic wounds, cardiovascular injury, tumors, and bacterial infections, aiming to enhance
Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, Xuanming Che, Tengjiao Wang, Hongbo Wei, Peng Li   +9 more
wiley   +1 more source

Therapy related acute myeloid leukemia secondary to CAR-T therapy in refractory/relapsed multiple myeloma patient showing poor prognosis. [PDF]

Ann Hematol
An R, Bao W, Yan Z, Sun H, Xu X, Zhang S.   +5 more
europepmc   +1 more source

Minimally Invasive Chemical Biopsy Needle with Self‐Wettable Extraction Phase For In Vivo Tissue Sampling During Medical Procedures

Advanced Science, EarlyView.
A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang, Wei Zhou, Marcelo Cypel, Todd L. Demmy, Gal Shafirstein, Guillermo Garza, Emily Gawrys, Joanna Bogusiewicz, Barbara Bojko, Janusz Pawliszyn   +9 more
wiley   +1 more source

Association between body mass index and survival after hematopoietic stem cell transplantation. [PDF]

Korean J Intern Med
Baek HS, Lee JH, Lee J, Lee SH, Min GJ, Park SS, Park S, Lee SE, Cho BS, Eom KS, Kim YJ, Lee S, Kim HJ, Min CK, Cho SG, Lee JW, Yoon JH.   +16 more
europepmc   +1 more source