Results 211 to 220 of about 159,123 (340)

Resident Macrophage‐Orchestrated Immune and Fibroblast Interactions in Immune Checkpoint Inhibitor‐Associated Nephrotoxicity

Advanced Science, EarlyView.
Schematic illustration of resident macrophages in Immune checkpoint inhibitor‐associated nephrotoxicity (ICI‐AN). Using an integrated approach (including imaging mass cytometry, transcriptomics, and murine models), this study reveals that resident macrophages drive immune‐stromal interactions in ICI‐AN, promoting fibroblast activation through CXCL9 and
Yanhong Ma, Yang Chen, Qinfan Yao, Yuxi Wang, Nan Ouyang, Fei Han, Guzong Wang, Meifang Wang, Yuan Yuan, Jianghua Chen, Jianzhen Shan, Dajin Chen   +11 more
wiley   +1 more source

Clonal hematopoiesis and subsequent venous thromboembolism among survivors of autologous transplantation for lymphoma. [PDF]

J Natl Cancer Inst
Gangaraju R, Chen Y, Hageman L, Bosworth A, Ross E, Francisco L, Singh P, Richard MA, Yan C, Kalra R, Cheng C, Armenian SH, Forman SJ, Bhatia R, Bhatia S.   +14 more
europepmc   +1 more source

Megasphaera Elesdenii Dysregulates Colon Epithelial Homeostasis, Aggravates Colitis‐Associated Tumorigenesis

Advanced Science, EarlyView.
A fecal microbial meta‐analysis reveals that Megasphaera is highly abundant in the Asian population with IBD and CRC. M. elsdenii reshapes colonic immunity by triggering DC cell‐mediated Th1 and Th17 inflammation. M. elsdenii and M. elsdenii‐enriched microbiota exacerbate colonic inflammation and tumorigenesis in AOM/DSS mice.
Xinxin Hou, Zhaozhou Zhang, Wanqing Chen, Jinming Li, Xiangxiang Zhu, Mingjie Li, Xiaoqi Guan, Haidong Guo, Yanlei Ma, Ling Zhao   +9 more
wiley   +1 more source

Prevalence of skin cancers in kidney transplant recipients - one-center experience. [PDF]

Front Oncol
Kosko F, Dębska-Ślizień A, Imko-Walczuk B, Piesiaków ML, Biedunkiewicz B, Bułło-Piontecka B, Bzoma B, Chamienia A, Gołębiewska J, Konopa J, Król E, Liberek T, Lichodziejewska-Niemierko M, Lizakowski S, Rutkowski P, Tarasewicz A, Wczysla M, Heleniak Z.   +17 more
europepmc   +1 more source

PSMD14‐Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression

Advanced Science, EarlyView.
This study investigates the expression and functional role of the deubiquitinase PSMD14 in PC, with a focus on the mechanism by which it promotes lactate accumulation–induced histone lactylation, thereby driving aberrant lipid metabolism. These findings establish that dual targeting of PSMD14 and the glycolysis–lactylation signaling axis may represent ...
Ri‐Shang Lu, Li‐Kun Ren, Xiao‐Bin Fei, Song‐Bai Liu, Yong‐Jia Gao, Jun‐Yi Hou, Chi Wang, Peng Liu, Chang‐Hao Zhu, Xing Wang, Yao‐Zhen Pan   +10 more
wiley   +1 more source

Impact of Induction Therapy in Low Immunological Risk Simultaneous Pancreas-Kidney Transplantation. [PDF]

Transpl Int
Montagud-Marrahi E, Rodriguez-Gonzalo A, Vidiella-Martin J, Álvarez BM, Gaston Ramírez I, Baronet A, Ferrer-Fàbrega J, Amor AJ, Ramírez-Bajo MJ, Musquera M, Diekmann F, Ventura-Aguiar P.   +11 more
europepmc   +1 more source

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan, Xin Qin, Li Gong, Haining Liu, Bo Cheng, Jing Wang, Yajie Hu, Lingxing Zeng, Yiping Wang, Qingxu Song, Yufeng Cheng   +10 more
wiley   +1 more source

Different clearance of KITD816V mutation and tryptase levels after haematopoietic cell transplantation in patients with systemic mastocytosis with associated haematological neoplasm. [PDF]

Br J Haematol
Niederwieser C, Badbaran A, Massoud R, Gagelmann N, Kunte A, Klyuchnikov E, Seyedi N, Heidenreich S, Rudolph I, Zeck G, Lück C, Janson D, Wolschke C, Ayuk F, Kröger N.   +14 more
europepmc   +1 more source

Src Reduces Neutrophil Extracellular Traps Generation and Resolves Acute Organ Damage

Advanced Science, EarlyView.
Src reduces neutrophil extracellular traps (NETs) generation and resolves acute organ damage. Src directly activates RAF1 by regulating phosphorylation at the Ser 621 site and mediates the RAF/MEK/ERK pathway, thereby affecting the intracellular ROS production. Alternatively, Src activates the RAF1/MEK/ERK pathway by mediating PKC phosphorylation.
Guotao Lu, Fei Han, Yaodong Wang, Chenchen Yuan, Qingtian Zhu, Tianqi Xia, Lin Chen, Xiaowu Dong, Yanbing Ding, Weiming Xiao, Yuyan Zhang, Jiajia Pan, Hongwei Xu, Weiwei Chen, Bo Tu, Wei Li, Fei Wang, Weijuan Gong, Lianghao Hu   +18 more
wiley   +1 more source

Alveolar Echinococcosis Mimicking Perihilar Cholangiocarcinoma Leading to Liver Transplant: A Case Report. [PDF]

Am J Case Rep
Premec H, Barišić-Jaman M, Dinjar Kujundžić P, Sobočan N, Mijić M, Lalovac M, Paštrović F, Matišić V, Grgurević I, Filipec-Kanižaj T.   +9 more
europepmc   +1 more source