Results 261 to 270 of about 76,990 (339)

Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Advanced Science, EarlyView.
The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen, Marie Lafitte, Maud Barbery, Kevin Espie, Maya Jeitany, Romain Larive, Jihane Vitre, Conception Paul, Yvan Boublik, Elise Fourgous, Valérie Simon, Audrey Sirvent, Madeline Neiveyans, Steeve Thirard, Lucile Bansard, Morgan Maillard, Nathalie Coutry, Jacques Colinge, Philippe Jay, Pierre Martineau, Michael Hahne, Julie Pannequin, Serge Roche   +22 more
wiley   +1 more source

Contribution of organ transplantation to the biology of cancer [PDF]

, 1990
Starzl, TE
core  

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

Advanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie, Tianyi Ji, Zixin Wan, Jie Huang, Han Li, Lingjiao Zou, Zhen Yang, Jiarui Li, Yuqi Guan, Lei Ruan, Jinhua Yan, Cuntai Zhang   +11 more
wiley   +1 more source

Myelomastocytic transformation in chronic myeloid leukemia blast phase: A case report. [PDF]

J Hematop
Al-Mashdali AF, Ibrahim F, Kohla S, Ganwo I, Akiki S, Abdulgayoom M, Yassin MA.   +6 more
europepmc   +1 more source

Outcomes with Allogeneic Hematopoietic Stem Cell Transplantation in Therapy Related Myeloid Neoplasms: A Systematic Review and Meta-Analysis [PDF]

Moazzam Shahzad, Muhammad Kashif Amin, Muhammad Fareed Khalid, Amir Kasaeian, Iman Menbari Oskouie, James Yu, Sarmad Zaman Warraich, Ahmad Basharat, Atif Saleem Butt, Maheen Zaidi, Iqra Anwar, Michael Jaglal, Muhammad Umair Mushtaq   +12 more
openalex   +1 more source

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

Advanced Science, EarlyView.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang   +13 more
wiley   +1 more source

A 31-year-old male with a plasmacytoid dendritic blast cell neoplasm. [PDF]

Ecancermedicalscience
Hernández DC, Rueda DÁ, Rapan L, Iastrebner M, Sorrentino M.   +4 more
europepmc   +1 more source

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
wiley   +1 more source

Clonal hematopoiesis in AML long-term survivors: Risk factors and clinical consequences. [PDF]

Hemasphere
Krauß SM, Telzerow E, Richter D, Moret AS, Rothenberg-Thurley M, Sauerland C, Weigert A, Fraccaroli A, Tischer J, Ziemann F, Götze KS, Berdel WE, Wörmann B, Krug U, Braess J, Heussner P, Enard W, Hiddemann W, Spiekermann K, Görlich D, Platzbecker U, Metzeler KH.   +21 more
europepmc   +1 more source