Results 151 to 160 of about 26,924 (226)

Dexmedetomidine Blocks the ERK Pathway by Inhibiting MAP3K8 to Achieve a Protective Effect in Lung Ischemia/Reperfusion Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Lung ischemia/reperfusion injury (LIRI) is a primary contributor to morbidity and mortality following lung transplantation. Dexmedetomidine (DEX) protects the lungs from I/R injury, but the underlying mechanisms remain uncertain. This paper examined the protective effect of DEX in LIRI and elucidated the potential regulation involved. LIRI was
Chun‐Huan Hu, Ru Qian, Yong‐Bo Wang, Lian‐Di Li, Chun‐Xing Miao   +4 more
wiley   +1 more source

Rectal Neuroendocrine Tumor With Non-Atypical Mucous Cell Glands: A Case Report. [PDF]

JGH Open
Ishikawa A, Tanaka H, Yamashita K, Oka S, Mii S.   +4 more
europepmc   +1 more source

HPV6‐Induced Gene Expression Signature in Recurrent Respiratory Papillomatosis

The Laryngoscope, EarlyView.
Using the conditional reprogramming method, we established a cell culture model of recurrent respiratory papillomatosis and analyzed gene expression. Genes related to human papillomavirus 6 expression were identified, including inflammatory genes (e.g., CTSS, CFB), oncogenic genes (e.g., CEACAM5, CEACAM6), and glycosylation‐associated genes (e.g ...
Naoyuki Matsumoto, Satoshi Ueha, Rumi Ueha, Misaki Koyama, Kaoru Yamakawa, Taku Sato, Takao Goto, Takeyuki Kono, Shigeyuki Shichino, Kouji Matsushima, Kenji Kondo   +10 more
wiley   +1 more source

Breast phyllodes tumour with epithelioid feature predisposes to malignant transformation. [PDF]

J Clin Pathol
Shao M, Zhang L, Li X, Bi J, Jiang X, Yu X, Liang Y, Xu H, Meng G, Gong X.   +9 more
europepmc   +1 more source

M1 Macrophage Extracellular Vesicles and TLR3 Agonist Nanoparticles Down‐Regulate Immunosuppression and Metastasis via AKT/TAM in Triple‐Negative Breast Cancer

Molecular Carcinogenesis, EarlyView.
ABSTRACT Metastasis induced by tumor immune escape has been implicated as one of the factors contributing to the aggressiveness of triple‐negative breast cancer. Macrophage type 1‐derived extracellular vesicles were isolated and combined with PLGA nanoparticles loaded with the TLR3 agonist poly I:C as a therapeutic strategy to investigate their ...
Shirley V. de Paiva Souza, Andreza Conceição Veras Aguiar, Elizabeth Costa S. de Albuquerque, Christina Eich, Luis J. Cruz, Pablo Lara, Carla Jorquera‐Cordero, Raelle Ferreira Gomes, Regina Célia Monteiro de Paula, Rosemayre S. Freire, de Araújo Júnior Raimundo Fernandes de AraújoJúnior   +10 more
wiley   +1 more source

Stromal Cells, Extracellular Matrix Components, and Adenosine A3 Receptor in Prostate Biopsies: Association With Histological Grade, PSA Levels, and Clinical Tumor Stage. [PDF]

J Histochem Cytochem
Pérez-Barraza N, Acuña P, San Martín S, Varas J, Cordova C, Casalino R, Madrid E.   +6 more
europepmc   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

A case of well-differentiated neuroendocrine tumor of the appendix in a 14-year-old male adolescent clinically presented with features of acute appendicitis: A case report and literature review. [PDF]

Int J Surg Case Rep
Reta BK, Gebrecherkos YB, Gebremichael YL, Hagos HH, Dojamo DD, Wubalem SM.   +5 more
europepmc   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, EarlyView.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Uterine cervical adenomyoma: Case report and literature review. [PDF]

Medicine (Baltimore)
Shi G, Wang Y, Liu Y, Fan XH, Zhao RH.
europepmc   +1 more source