Cancer Science, EarlyView.A humanized cancer‐specific anti‐podoplanin monoclonal antibody humPMab‐117 exerts antibody‐dependent cellular cytotoxicity and complement‐dependent cytotoxicity against human tumor cells. In the xenograft tumor models, humPMab‐117 demonstrated strong antitumor efficacy.
Tomohiro Tanaka +5 more
wiley +1 more source
Liquid-based Cytological Features of Adenocarcinoma Not Otherwise Specified, Extrauterine Adenocarcinoma, and Other Malignant Neoplasms of The Uterine Cervix: A 5-year Single-institutional Experience With 30 Consecutive Patients. [PDF]
In VivoKum SJ, Choi S, Kim HS.
europepmc +1 more source
Cancer Science, EarlyView.We have demonstrated that prestimulation of human lung cancer cells with TGF‐β enhances resistance to doxorubicin‐induced growth inhibition, depending on Smad3 and Smad4 through induction of ALDH1A1. Knockdown of ALDH1A1 suppressed TGF‐β‐induced resistance to doxorubicin, and exogenous expression of ALDH1A1 in SMAD3‐KO cells restored the drug ...
Takashi Yokoyama +2 more
wiley +1 more source
Periductal stromal tumor of the breast; Can we expect the diagnosis? A case report and literature review. [PDF]
Int J Surg Case RepHamdy O +4 more
europepmc +1 more source
Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women
Clinical Endocrinology, EarlyView.ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan +14 more
wiley +1 more source
Gastric Epithelial Neoplasms in Patients with Pulmonary Arterial Hypertension Receiving Continuous Intravenous Prostacyclin Therapy. [PDF]
J Clin MedMannami T +11 more
europepmc +1 more source
Investigating Aging‐Related Endometrial Dysfunction Using Endometrial Organoids
Cell Proliferation, Volume 58, Issue 4, April 2025.Age‐associated fibrosis, imbalanced inflammatory homeostasis including Th1 bias in secretory phase, cellular senescence and decline of receptivity exist in human endometrium of advanced age. Overactivation of PI3K‐AKT‐FOXO1 signalling pathway could give rise to those characteristics above.
Minghui Lu +9 more
wiley +1 more source
A rare cutaneous neoplasm in an elderly patient. [PDF]
JAAD Case RepAlzahrani N +3 more
europepmc +1 more source
HN1 Functions in Protein Synthesis Regulation via mTOR‐RPS6 Axis and Maintains Nucleolar Integrity
Cell Proliferation, EarlyView.HN1 is required for nucleolar homeostasis which is the site of ribosome biogenesis and protein synthesis when its mRNA is knocked down by shRNA, it depletes in cytoplasm and the protein synthesis is downregulated in comparison to controls. Thus, the proliferating cells requiring vast number of nucleosomes, are arrested at S onset.
Gülseren Özduman +4 more
wiley +1 more source
Practical hints for the diagnosis of mixed neuroendocrine-non-neuroendocrine neoplasms of the digestive system. [PDF]
World J Gastrointest OncolMattiolo P.
europepmc +1 more source