Results 121 to 130 of about 9,604,418 (279)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The Case Report of Multiple Primary Malignant Neoplasms

Three cases of multiple primary malignant neoplasms in our ENT-clinic for past five years were reported. In the same period, we had 4,846ENT-patients and228 ENT- malignant tumor patients; i.e., the incidence of multiple primary malignant neoplasm to the ...
Kurita, Ken-ichi, 又吉, 重光, 栗田, 建一, Miyakogawa, Norimasa, Arakaaki, Yoshitaka, 野田, 寛, Noda, Yutaka, 都川, 紀正, Matayoshi, Shigemitsu, 新垣, 義孝   +9 more
core  

MULTIPLE PRIMARY MALIGNANT NEOPLASMS FROM EASTERN BLACK SEA REGION OF TURKEY: SINGLE CENTER EXPERIENCE

, 2016
Objective: The incidence of multiple primary malignant neoplasms (MPMN) has been increasing worldwide. MPMN emerging after radiation therapy (RT) change in between the RT-centers and regions. In this study, we aimed to analyze the data on MPMN in a group
Yoney, Adnan, BAHAT, ZÜMRÜT, CANYILMAZ, EMİNE, Memis, Yahyahan, KANDAZ, MUSTAFA, Kavgaci, Halil   +5 more
core  

Oncotype Dx Results in Multiple Primary Breast Cancers

, 2014
Purpose To determine whether multiple primary breast cancers have similar genetic profiles, specifically Oncotype Dx Recurrence Scores, and whether obtaining Oncotype Dx on each primary breast cancer affects chemotherapy recommendations.
Kelley M. Kidwell, Michael J. Toole, Catherine Van Poznak   +2 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The Utility and Limitation of Thyroid Transcription Factor-1 Protein in Primary and Metastatic Pulmonary Neoplasms

, 2009
Thyroid transcription factor-1 (TTF-1) is a tissue-specific transcription factor expressed in the thyroid and Lung. The clinical utility and limitation of TTF-1 in primary or metastatic carcinomas of the lung have not been previously studied in detail ...
CHANG, YIH-LEONG;LEE, YUNG-CHIE;LIAO, WEI-YU;WU, CHEN-TU, 張逸良;李元麒;廖唯昱;吳振都   +1 more
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Mucinous Neoplasms

, 2015
Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, it is still the case that less is known about pathology of the pancreas than about liver pathology, for example.
D'ONOFRIO, Mirko, Capelli, Paola, MORANA, Giovanni, DE ROBERTIS LOMBARDI, Riccardo, Barbi, Emilio, TINAZZI MARTINI, Paolo, LUCHINI, Claudio, Crosara, Stefano   +7 more
core  

Multiple primary malignant neoplasms: Data of Cumhuriyet University

, 2012
Amaç. Onkolojik tedavilerdeki gelişmeler ve beklenen yaşam süresinin uzaması, tedavilerin geç yan etkileri ve ikinci kanserlerin gelişimi gibi sorunları da beraberinde getirmiştir.
Ebru Akkaş Atasever, Saadettin Kılıçkap, Turgut Kaçan, Şafak Şahin, Nalan Babacan Akgül, Mehmet Fuat Eren, Birsen Yücel, Yıllar Okur   +7 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source