Results 61 to 70 of about 221,735 (309)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Mathematical model of skin autofluorescence induced by 450 nm laser

Journal of Biomedical Photonics & Engineering, 2018
Optical methods are increasingly being used for the early diagnosis of skin cancer. This approach allows for detecting the component composition changes of tissue in a non-invasive manner.
Dmitry N. Artemyev
doaj   +1 more source

Morphological analysis of CDC2 and glycogen synthase kinase 3β phosphorylation as markers of g2 → m transition in glioma. [PDF]

, 2011
G2 → M transition is a strategic target for glioma chemotherapy. Key players in G2 → M transition include CDC2 and glycogen synthase kinase 3β (GSK3β), which are highly regulated by posttranslational phosphorylation.
Otero, José Javier, Tihan, Tarik
core   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades

Radiation Oncology, 2017
Radiation-induced pneumonitis and fibrosis represent severe and dose-limiting side effects in the radiotherapy of thorax-associated neoplasms leading to decreased quality of life or - as a consequence of treatment with suboptimal radiation doses - to ...
Florian Wirsdörfer, Verena Jendrossek
doaj   +1 more source

Assessing radiation-induced carotid vasculopathy using ultrasound after unilateral irradiation: a cross-sectional study

Radiation Oncology, 2022
Background Increased head and neck cancer (HNC) survival requires attention to long-term treatment sequelae. Irradiated HNC survivors have a higher ischemic stroke risk. However, the pathophysiology of radiation-induced vasculopathy is unclear.
Judith T. Pruijssen, Joyce Wilbers, Frederick J. A. Meijer, Sjoert A. H. Pegge, Jacqueline J. Loonen, Chris L. de Korte, Johannes H. A. M. Kaanders, Hendrik H. G. Hansen   +7 more
doaj   +1 more source

Expression and intracellular localization of FKHRL1 in mammary gland neoplasms. [PDF]

, 2004
FKHRL1 (FOXO3a), a member of the Forkhead family of genes, has been considered to be involved in the development of breast tumors; however, the in vivo expression and activation status of FKHRL1 in breast tumors still remains unclear.
Akagi, Tadaatsu, Hayashi, Kazuhiko, Jin, Gui-Shan, Kondo, Eisaku, Liu, Yi-Xuan, Miyake, Takayoshi, Shibata, Masao, Takashima, Takako, Yoshino, Tadashi   +8 more
core   +1 more source

Intramedullary Glioblastoma as One of Multiple Radiation-Induced Neoplasms

Case Reports in Oncology
Introduction: Intramedullary glioblastoma is a rare entity comprising 1.4–9% of spinal gliomas. Spinal cord radiation-induced gliomas are unique, with only 13 cases reported to date. Case Presentation: A 53-year-old female with a history of mediastinal Hodgkin lymphoma treated with chemotherapy and radiotherapy who subsequently developed thyroid cancer
Koczyk, Kacper, Nowak, Arkadiusz, Machnicki, Marcin M., Michałowski, Łukasz Zdzisław, Maj, Edyta, Stoklosa, Tomasz, Kunert, Przemysław   +6 more
openaire   +2 more sources

Time Dependence of Radiation-induced Hypothalamic–Pituitary Axis Dysfunction in Adults Treated for Non-pituitary, Intracranial Neoplasms [PDF]

Clinical Oncology, 2017
AIMS: Hypothalamic-pituitary axis (HPA) dysfunction is a sequela of cranial radiotherapy. The purpose of this study was to use endocrine data from existing publications to characterise the baseline endocrine status, the effects of radiotherapy on the HPA during the first follow-up year and the time dependence of radiation-induced HPA dysfunction in ...
Taku, N, Gurnell, M, Burnet, N, Jena, R
openaire   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source