Results 91 to 100 of about 1,822,518 (269)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

P198 | BONE MARROW FIBROSIS IN POLYCYTHEMIA VERA AND ESSENTIAL THROMBOCYTHEMIA: CLINICAL, MOLECULAR AND PROGNOSTIC IMPLICATIONS

Haematologica
Background Mild BM fibrosis (MF-1) can be identified in up to 20% of patients (pts) with polycythemia vera (PV) and essential thrombocytemia (ET), and may play a role –albeit still poorly defined–in pathophysiology, clinical presentation ad long-term ...
G. Coltro, G. Borgi, V. Boldrini, F. Gesullo, F. Violi, M. Balliu, P. Guglielmelli   +6 more
doaj  

Differential Expression Patterns of Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUPTFII) in Primary Renal Cell Neoplasms [PDF]

, 2014
Zhenjian Cai, Amad Amad Awadallah, Ming Zhou, Cristina Magi‐Galluzzi, Xin Wei   +4 more
openalex   +1 more source

PB2007: INTEGRATION OF TELEHEALTH IN DAILY CLINICAL PRACTICE IN PATIENTS WITH MYELODYSPLASTIC NEOPLASMS - STATUS QUO AND FUTURE PERSPECTIVES

, 2023
Reinhard Stauder, Adrian Lühring, Stefanie Tipelius, Gerhard Rumpold, Patrick Künstner   +4 more
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Paired organoids from primary gastric cancer and lymphatic metastasis are useful for personalized medicine

Journal of Translational Medicine
Background Organoids are approved by the US FDA as an alternative to animal experiments to guide drug development and for sensitivity screening. Stable organoids models of gastric cancer are desirable for personalized medicine and drug screening. Methods
Ruixin Yang, Yao Qi, Wingyan Kwan, Yutong Du, Ranlin Yan, Lu Zang, Xuexin Yao, Chen Li, Zhenggang Zhu, Xiaoyan Zhang, Hengjun Gao, Io Hong Cheong, Zisis Kozlakidis, Yingyan Yu   +13 more
doaj   +1 more source

Appendiceal Mucinous Neoplasm in Fourth Decade of Life. Report of a Case [PDF]

, 2022
Torres-Salazar Quitzia
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

P980: THE ROLE OF PLATELET AND ENDOTHELIAL MICROPARTICLES AND DOPPLER ULTRASOUND SCREENING IN THE ASSESSMENT OF THROMBOTIC READINESS IN MULTIPLE MYELOMA AND NON HODGKIN LYMPHOMA, PROSPECTIVE STUDY

HemaSphere, 2023
Magdalena Olszewska-Szopa, Urszula Zaleska-Dorobisz, Agnieszka Zubkiewicz-Kucharska, Iwona Prajs, Tomasz Wróbel, Lidia Usnarska-Zubkiewicz   +5 more
doaj   +1 more source