Results 161 to 170 of about 1,891,938 (317)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Investigation of the Intensity of Thrombocytosis as a Potential Prognostic Indicator in Canine Malignant Neoplasms. [PDF]

Vet Med Int
Souto LG, Teng FS, Vieira SE, Takahira RK.   +3 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Pain Catastrophizing After Early-Stage Lung Cancer Surgery: The Mediating Effects of Interoceptive Awareness, Negative Attentional Bias, and Social Support

Journal of Pain Research
Guanjun Bian,1,2 Xiaoting Sun,2 Qing Chang,1 Lifeng Liu,1 Chunmei Zhang3 1Department of Pulmonary Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and ...
Bian G, Sun X, Chang Q, Liu L, Zhang C
doaj  

? Neoplasm of Lung. [PDF]

Proceedings of the Royal Society of Medicine, 1921
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Induction of mammary neoplasms in the ACI rat by 430-keV neutrons, X-rays, and diethylstilbestrol [PDF]

, 1982
Kellerer, Albrecht M., Holtzman, S., Chmelevsky, D., Stone, J. P., Shellabarger, C. J.   +4 more
core   +1 more source

C030 | GENOTYPE-PHENOTYPE CORRELATES AND OUTCOMES OF EXTRAMEDULLARY ACUTE MYELOID LEUKEMIA

Haematologica
Background: Genomic abnormalities associated with extramedullary (EM) acute myeloid leukemia (eAML) and their impact on clinical outcomes are not well understood since previous studies were limited to small case series with controversial results.
G.G. Loscocco, F. Mannelli, M. Piccini, B. Scappini, F. Crupi, G. Ciolli, L. Fasano, G. Rotunno, F. Pancani, C. Maccari, L. Signori, P. Guglielmelli, A.M. Vannucchi   +12 more
doaj  

Primary Cardiac Neoplasms: A 12-Year Institutional Experience at a National Cardiac Referral Center in Mexico. [PDF]

Cureus
Bernal Armenta A.
europepmc   +1 more source