Results 281 to 290 of about 1,230,212 (337)

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Primary exploration of cell-free DNA in the plasma of patients with parathyroid neoplasms using next-generation sequencing. [PDF]

Cancer Cell Int
Zheng Q, Cui M, Wang O, Chang X, Xiao J, Chen T, Wang M, Hua S, Hu Y, Liao Q.   +9 more
europepmc   +1 more source

EXTENSIVE OCULO-PALPEBRAL NEOPLASM; EXCISION OF LIDS AND ENUCLEATION OF THE EYEBALL, FOLLOWED BY OCCLUSION OF THE ORBIT

, 1934
E. Puscariu
openalex   +1 more source

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

Synchronous Endometrial and Ovarian Adenocarcinomas in a 43-Year-Old Patient Following Infertility Treatment: A Case Report. [PDF]

Diagnostics (Basel)
Gajewska M, Suchońska B, Blok J, Gajzlerska-Majewska W, Ludwin A.   +4 more
europepmc   +1 more source

NEOPLASMS OF THE ABDOMINAL WALL WITH SPECIAL REFERENCE TO MALIGNANT “IMPLANTATION” TUMORS

, 1938
Joseph A. Lazarus
openalex   +2 more sources

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Intraoperative collaboration between surgeons and endoscopists who performed previous endoscopic ultrasound in laparoscopic ultrasound-guided pancreatic tumor enucleation. [PDF]

Endoscopy
Maehara K, Okubo S, Hirano K, Hattori D, Sato Y, Koyama R, Imamura T.   +6 more
europepmc   +1 more source

FIVE CASES OF PRIMARY URETERAL NEOPLASM

, 1951
Taro Iwasaki, Toyokazu Saito, Keiichi Fujita, Takashi Kishimoto   +3 more
openalex   +2 more sources

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source