Results 61 to 70 of about 1,230,212 (337)

Network-based community detection of comorbidities and their association with SARS-CoV-2 virus during COVID-19 pathogenesis [PDF]

arXiv, 2022
Recent studies emphasized the necessity to identify key (human) biological processes and pathways targeted by the Coronaviridae family of viruses, especially SARS-CoV-2. COVID-19 caused up to 33-55\% death rates in COVID-19 patients with malignant neoplasms and Alzheimer's disease.
arxiv  

Low-Grade Appendiceal Mucinous Neoplasm Involving the Endometrium and Presenting with Mucinous Vaginal Discharge. [PDF]

, 2016
Primary appendiceal mucinous lesions are uncommon and represent a spectrum from nonneoplastic mucous retention cysts to invasive adenocarcinoma. Low-grade appendiceal mucinous neoplasms (LAMNs) represent an intermediate category on this spectrum and can ...
Baumgartner, Joel M, Ko, Albert, Saenz, Cheryl C, Valasek, Mark A, Vavinskaya, Vera   +4 more
core   +4 more sources

Is pneumoperitoneum the terra ignota in ultrasonography?

Journal of Ultrasonography, 2015
In most cases, pneumoperitoneum is caused by gastrointestinal perforation, which usually requires surgical treatment. Many authors believe that ultrasound imaging of pneumoperitoneum is at least as effective as conventional radiography, or even that ...
Andrzej Smereczyński, Katarzyna Kołaczyk   +1 more
doaj   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Leveraging big data and artificial intelligence for smarter trials in myeloproliferative neoplasms

Frontiers in Hematology
The myeloproliferative neoplasms (MPNs) – polycythemia vera, essential thrombocytosis, and primary myelofibrosis – are chronic blood cancers that originate from hematopoietic stem cells carrying driver mutations which activate cytokine signaling pathways
Joshua W. Bliss, Spencer Krichevsky, Spencer Krichevsky, Joseph Scandura, Ghaith Abu-Zeinah   +4 more
doaj   +1 more source

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, EarlyView.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

JulianA: An automatic treatment planning platform for intensity-modulated proton therapy and its application to intra- and extracerebral neoplasms [PDF]

arXiv, 2023
Creating high quality treatment plans is crucial for a successful radiotherapy treatment. However, it demands substantial effort and special training for dosimetrists. Existing automated treatment planning systems typically require either an explicit prioritization of planning objectives, human-assigned objective weights, large amounts of historic ...
arxiv  

Formation of Pancreatoduodenal Fistula in Intraductal Papillary Mucinous Neoplasm of the Pancreas Decreased the Frequency of Recurrent Pancreatitis [PDF]

, 2019
Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are characterized by proliferation of mucin-secreting cells in the main pancreatic duct (PD) or its branches. The secreted thick mucin usually leads to PD obstruction and dilation.
Alkaade, Samer, Hammami, Muhammad B., Khneizer, Gebran, Reddy, Kavya M.   +3 more
core   +1 more source

Is adjuvant chemotherapy necessary for early gastric cancer?

Cancer Biology & Medicine, 2022
Objective: To quantify the potential benefit of adjuvant chemotherapy (ACT) with respect to survival, and to identify factors for predicting prognoses in early gastric cancer patients.
Yu Mei, Tienan Feng, Min Yan, Zhenggang Zhu, Zhenglun Zhu   +4 more
doaj   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source