Results 61 to 70 of about 1,822,518 (269)

Deciphering of intra‐tumoural heterogeneity and the interplay between metastasis‐associated meta‐program and myofibroblasts in gastric cancer

Clinical and Translational Medicine
Background Gastric cancer (GC) exhibits high heterogeneity that relies on the oncogenic properties of cancer cells and multicellular interactions in the tumour microenvironment.
Xiongyan Wu, Zhijian Jin, Baolong Li, Yifan Lu, Junyi Hou, Lizhong Yao, Zhenjia Yu, Qingqing Sang, Beiqin Yu, Jianfang Li, Chen Li, Chao Yan, Zhenggang Zhu, Kaiwen Tang, Bingya Liu, Liping Su   +15 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

DP133 | CIP2A IS IMPLICATED IN RUXOLITINIB RESISTANCE IN MYELOFIBROSIS

Haematologica
Although ruxolitinib (Ruxo) is the standard of care for patients (pts) with myelofibrosis (MF), therapeutic resistance develops in approximately 50% within 3-5 years, posing a clinical challenge.
M. Balliu, M. Vannucchi, M.C. Siciliano, M. Lomi, C. Basile, P. Guglielmelli, A.M. Vannucchi   +6 more
doaj  

Prognostic factors in patients with Hürthle cell neoplasms of the thyroid [PDF]

, 2003
Luis Lopez‐Penabad, Alice C. Chiu, Ana O. Hoff, Pamela N. Schultz, Sonia Gaztambide, Nelson G. Ordóǹez, Steven I. Sherman   +6 more
openalex   +1 more source

A novel ETV6::FGFR1 fusion gene in a myeloid/lymphoid neoplasm with FGFR1 rearrangement sensitive to specific FGFR1-2-3 inhibition

, 2023
Carlos Jiménez‐Vicente, Marta Garrote, Mònica López‐Guerra, Eva Villamón, Francesca Guijarro, Amanda Isabel Pérez‐Valencia, Alexandra Martinez-Roca, Olga Balaguer, Alberto Álvarez‐Larrán, Juan Carlos Hernández‐Boluda, Montserrat Rovira, Dolors Colomer, Marina Díaz‐Beyá, Marı́a Rozman, Jordi Esteve   +14 more
openalex   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Incidence, Survival and Prevalence Statistics of Classical Myeloproliferative Neoplasm in Korea [PDF]

, 2016
Yoojoo Lim, Jeong‐Ok Lee, Soo‐Mee Bang   +2 more
openalex   +1 more source

Prognostic Enigma of Pancreatic Solid Pseudopapillary Neoplasm: A Single-Center Experience of 63 Patients [PDF]

, 2021
Xinbo Wang, Daojun Zhu, Wei Bao, Min Li, Sizhen Wang, Rongxi Shen   +5 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The value of intraoperative consultation (frozen section) in the diagnosis of ovarian neoplasms [PDF]

, 1998
Alp Usubutün, Gülçin Altínok, T. Küçükali   +2 more
openalex   +1 more source