Nature Communications, 2021 The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D ...
Roser Vilarrasa-Blasi +19 more
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Neoplastic transformation of breast epithelial cells by genotoxic stress [PDF]
BMC Cancer, 2010 Abstract Background Exposure to genotoxic stresses such as radiation and tobacco smoke can cause increased cancer incidence rate as reflected in an in depth meta-analysis of data for women and breast cancer incidence.
Raman Venu +2 more
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Eriodictyol inhibits RSK2-ATF1 signaling and suppresses EGF-induced neoplastic cell transformation. [PDF]
J Biol Chem, 2011 RSK2 is a widely expressed serine/threonine kinase, and its activation enhances cell proliferation. Here, we report that ATF1 is a novel substrate of RSK2 and that RSK2-ATF1 signaling plays an important role in EGF-induced neoplastic cell transformation.
Liu K +11 more
europepmc +2 more sources
PDZ-binding kinase/T-LAK cell-originated protein kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growth. [PDF]
Oncotarget, 2016 The fucoidan with high anticancer activity was isolated from brown alga Fucus evanescens. The compound effectively prevented EGF-induced neoplastic cell transformation through inhibition of TOPK/ERK1/2/MSK 1 signaling axis.
Vishchuk OS +12 more
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FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks [PDF]
Frontiers in Cell and Developmental BiologyPurposeFOS-like antigen 1 (FRA1), encoded by FOSL1, is an inducible subunit of the AP-1 transcription factor complex and regulates gene expression in response to proliferative and environmental cues.
Wuroud Al-Khayyat +14 more
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Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B [PDF]
Scientific Reports, 2019 AbstractBone marrow stromal (Mesenchymal) stem cells (MSCs) are multipotent bone cells capable of differentiating into mesoderm-type cells, such as osteoblasts and adipocytes. Existing evidence suggests that transformation of MSCs gives rise to sarcoma.
Radhakrishnan Vishnubalaji +12 more
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Environmental Health Perspectives, 1990 Neoplastic cell transformation induced by estrogens and some other carcinogens such as benzene appears to involve the induction of mitotic aneuploidy rather than DNA damage and point mutations.
Bernd Epe +3 more
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Mechanisms of radiation-induced neoplastic cell transformation [PDF]
, 1984 Studies with cultured mammalian cells demonstrated clearly that radiation can transform cells directly and can enhance the cell transformation by oncogenic DNA viruses. In general, high-LET heavy-ion radiation can be more effective than X and gamma rays in inducing neoplastic cell transformation.
Yang, T. C. H., Tobias, C. A.
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Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1 [PDF]
Carcinogenesis, 2007 Ki Won Lee +9 more
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Phosphorylation of Histone H3 at Serine 10 Is Indispensable for Neoplastic Cell Transformation [PDF]
Cancer Research, 2005 Hong Seok Choi +6 more
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