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Metabolic Plasticity of Tumor Cell Mitochondria [PDF]
Frontiers in Oncology, 2018 Mitochondria are dynamic organelles that exchange a multiplicity of signals with other cell compartments, in order to finely adjust key biological routines to the fluctuating metabolic needs of the cell.
Giuseppe Cannino +4 more
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Emerging roles of telomeric chromatin alterations in cancer [PDF]
Journal of Experimental & Clinical Cancer Research, 2019 Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Stefano Cacchione +2 more
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FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks [PDF]
Frontiers in Cell and Developmental BiologyPurposeFOS-like antigen 1 (FRA1), encoded by FOSL1, is an inducible subunit of the AP-1 transcription factor complex and regulates gene expression in response to proliferative and environmental cues.
Wuroud Al-Khayyat +14 more
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eLife, 2021 Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness.
Brian Spurlock +9 more
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Nature Communications, 2021 The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D ...
Roser Vilarrasa-Blasi +19 more
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Cumhuriyet Dental Journal, 2021 Objective. To assess the clinical-pathological factors related to the malignant transformation of oral leukoplakia. Materials and Methods. A search for articles on malignant transformation factors related to oral leukoplakia was conducted in the ...
Cristina Fuentes-perez +1 more
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Effects of Curcumin on Sodium Arsenite Induced Neoplastic Cell Transformation in Balb/c 3T3 Cells [PDF]
Brazilian Archives of Biology and Technology, 2021 HIGHLIGHTS Sodium arsenite can cause neoplastic transformation in cells. Curcumin reduced cell viability and increased LDH activity in transformed Balb/c 3T3 cells. Curcumin caused DNA damage in transformed Balb/c 3T3 cells.
Busra Demircioglu +4 more
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Elastic Moduli of Cells undergoing Neoplastic Transformation [PDF]
Biophysical Journal, 2013 Using an Atomic Force Microscope (AFM) with a 5.3 um diameter spherical probe we determined the elastic modulus of human mammary epithelial cells (HMEC) as they undergo neoplastic transformation from normal to immortal, tumorigenic, and finally metastatic. We did the measurements over both cytoplasmic and nuclear regions; and as a function of the cells
Guo, Xinyi +2 more
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Clinicopathologic characteristics of ovarian clear cell carcinoma in the background of endometrioma: a surveillance strategy for an early detection of malignant transformation in patients with asymptomatic endometrioma [PDF]
Obstetrics & Gynecology Science, 2019 ObjectiveThis study aimed to analyze the clinical features of clear cell carcinoma in relation to endometriosis and to determine an appropriate surveillance strategy for the early detection of malignant transformation of endometrioma in asymptomatic ...
Joo-Hyuk Son +6 more
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Alternative Splicing and Its Impact as a Cancer Diagnostic Marker [PDF]
Genomics & Informatics, 2012 Most genes are processed by alternative splicing for gene expression, resulting in the complexity of the transcriptome in eukaryotes. It allows a limited number of genes to encode various proteins with intricate functions.
Yun-Ji Kim, Heui-Soo Kim
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