Results 41 to 50 of about 3,546 (164)

Acquired central diabetes insipidus secondary to severe, chronic otitis media and interna in an 8‐year‐old Spanish Mastiff dog (canine)

Veterinary Record Case Reports, Volume 13, Issue 3, September 2025.
Abstract An 8‐year‐old spayed female Spanish Mastiff dog presented with a five‐month history of polyuria, polydipsia, persistent isosthenuria to hyposthenuria, urinary incontinence, and bilateral otitis externa, progressing to acute vestibular dysfunction.
Kevin Gooch, Kyle L. Granger Jr., Paula Yoon, Chris Olmo, Mei Lun Mui, Sarrah E. Hoppers, Kelly E. Hall   +6 more
wiley   +1 more source

Plasma Arginine Vasopressin and Serum Copeptin Concentrations at Rest and After Osmotic‐ and Non‐Osmotic‐Based Stimulation Tests in Dogs

Journal of Veterinary Internal Medicine, Volume 39, Issue 5, September/October 2025.
ABSTRACT Background Serum copeptin (sCoP) is used as a surrogate for plasma arginine vasopressin (pAVP) measurement in humans. Objective To measure pAVP and sCoP at rest and after osmotic‐ and non‐osmotic stimulation testing in dogs. Animals Eight young castrated/spayed healthy research Beagles, eight young intact dogs, and eight old neutered healthy ...
Mathieu Victor Paulin, Thomas Schermerhorn, Dorsa Mehrabanpour, Suraj Unniappan, Elisabeth Snead   +4 more
wiley   +1 more source

Use of copeptin in interpretation of the water deprivation test

Endocrinology, Diabetes & Metabolism, 2023
Introduction Currently, the water deprivation test remains the standard method for distinguishing primary polydipsia (PP) from cranial diabetes insipidus (cDI) and nephrogenic diabetes insipidus (nDI). There is increasing interest in a direct estimate of
Matthew Rowe, Nishchil Patel, Jinny Jeffery, Daniel Flanagan   +3 more
doaj   +1 more source

Perioperative Management of Lithium Therapy: Considerations and Recommendations

Bipolar Disorders, Volume 28, Issue 1, February 2026.
L. S. Dominicus, F. van Houwelingen, M. Marsman, G. Lefeber, I. Wilting, A. Dols   +5 more
wiley   +1 more source

Lithium‐induced kidney injury and fibrosis: A versatile model to explore cellular pathways of injury and repair

Physiological Reports, Volume 13, Issue 17, September 2025.
Abstract Lithium‐induced kidney injury is commonly associated with the development of nephrogenic diabetes insipidus. Longer term lithium exposure is associated with the development of chronic interstitial fibrosis. The mechanisms of lithium‐induced kidney injury are multifaceted, affecting many intracellular cell signaling pathways associated with ...
Paulomi Mehta, Tania Slatter, Robert Walker   +2 more
wiley   +1 more source

Nephrotoxicity and Modern Volatile Anesthetics: A Narrative Review

Toxics
Volatile anesthetics, while increasingly utilized in intensive care medicine, are associated with significant renal adverse effects. A critical safety concern—particularly with sevoflurane—involves its potential impact on renal function ...
Benedicte Hauquiert, Aurelien Gonze, Thibault Gennart, Emily Perriens, Sydney Blackman, Nathan De Lissnyder, Arnaud Robert, Julien Moury, Gauthier Nendumba, Ilann Oueslati, Priscilla Gillis, Ovidiu Vornicu, Anne-Sophie Dincq, Pierre Bulpa, Isabelle Michaux, Patrick M. Honore   +15 more
doaj   +1 more source

AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus

Nature Communications, 2018
Patients suffering from congenital nephrogenic diabetes insipidus (NDI) fail to concentrate urine due to mutations in vasopressin type 2 receptor (V2R). Here Ando et al.
Fumiaki Ando, Shuichi Mori, Naofumi Yui, Tetsuji Morimoto, Naohiro Nomura, Eisei Sohara, Tatemitsu Rai, Sei Sasaki, Yoshiaki Kondo, Hiroyuki Kagechika, Shinichi Uchida   +10 more
doaj   +1 more source

Pleiotropic Effects of the NSAID Fenamates on Chloride Channels: Opportunity for Ion Channelopathies?

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Chloride channels are involved in many cellular processes, including cell volume regulation, modulation of cell excitability, and electrolyte and water secretion. Mutations of these proteins are associated with heterogeneous diseases such as myotonia, cystic fibrosis, epilepsy, deafness, lysosomal storage disease, and various kinds of renal ...
Paola Laghetti, Ilaria Saltarella, Simone Dell'Atti, Jean‐François Desaphy, Concetta Altamura   +4 more
wiley   +1 more source

Use of acetazolamide in lithium-induced nephrogenic diabetes insipidus: a case report

Endocrinology, Diabetes & Metabolism Case Reports, 2018
Lithium-induced nephrogenic diabetes insipidus (Li-NDI) is a rare and difficult-to-treat condition. A study in mice and two recent papers describe the use of acetazolamide in Li-NDI in 7 patients (a case report and a 6 patient series).
Ricardo A Macau, Tiago Nunes da Silva, Joana Rego Silva, Ana Gonçalves Ferreira, Pedro Bravo   +4 more
doaj   +1 more source

Rescue of Epilepsy‐Associated Mutations of the Highly Conserved Glycine Residue 443 in the Human GABA Transporter 1

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
Mutations in the human GABA transporter 1 (hGAT‐1) gene impair GABA transport, leading to developmental disorders like epilepsy and autism. These mutations often disrupt protein folding. Pharmacochaperones can rescue transporter expression and function in heterologous cell lines and in Drosophila melanogaster, thus offering potential therapeutic ...
Nikita Shah, Vasylyna Kovalchuk, Rocco Zerlotti, Kim Cole, Andre Bazzone, Harald H. Sitte, Thomas Hummel, Ameya S. Kasture, Sonja Sucic   +8 more
wiley   +1 more source