Results 41 to 50 of about 3,615 (161)

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, Volume 14, Issue 4, Page 978-991, May 2026.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

Nature Communications, 2017
Nrf2 regulates oxidative and electrophilic stress responses by modulating the expression of enzymes involved in detoxification pathways. Here Suzukiet al.
Takafumi Suzuki, Shiori Seki, Keiichiro Hiramoto, Eriko Naganuma, Eri H. Kobayashi, Ayaka Yamaoka, Liam Baird, Nobuyuki Takahashi, Hiroshi Sato, Masayuki Yamamoto   +9 more
doaj   +1 more source

V2 vasopressin receptor mutations: future personalized therapy based on individual molecular biology

Frontiers in Endocrinology, 2023
The diluting and concentrating function of the kidney plays a crucial role in regulating the water homeostasis of the body. This function is regulated by the antidiuretic hormone, arginine vasopressin through the type 2 vasopressin receptor (V2R ...
László Sándor Erdélyi, László Hunyady, László Hunyady, András Balla, András Balla   +4 more
doaj   +1 more source

Postoperative polyuria after hepatectomy associated with prolonged sodium‐glucose co‐transporter‐2 inhibitor effect

Anaesthesia Reports, Volume 14, Issue 1, January‐June 2026.
Summary Sodium‐glucose co‐transporter‐2 inhibitors are routinely withheld before surgery to reduce the risk of peri‐operative metabolic complications. However, their pharmacodynamic effects may persist beyond the recommended discontinuation period. We report a 67‐year‐old man with type 2 diabetes who developed severe postoperative polyuria (6–7 l.day−1)
D. Tominaga, T. Okada, Y. Hosokawa, C. Tsuboi, H. Fukuoka, N. Obata   +5 more
wiley   +1 more source

Physiological basis of arginine vasopressin deficiency (AVP-D, formerly central diabetes insipidus) and AVP-resistance (AVP-R, formerly nephrogenic diabetes insipidus) [PDF]

Exploration of Medicine
This review explored the physiological mechanisms underlying arginine vasopressin deficiency (AVP-D, formerly central diabetes insipidus) and AVP resistance (AVP-R, formerly nephrogenic diabetes insipidus), with a focus on water balance regulation. Vital
Osah Martins Onwuka
doaj   +1 more source

Severe Diabetic Ketoacidosis With Refractory Hypernatremia due to Hypokalemia‐Induced Arginine Vasopressin Resistance: A Case Report and Literature Review

Case Reports in Medicine, Volume 2026, Issue 1, 2026.
Diabetic ketoacidosis (DKA) is a life‐threatening complication of diabetes characterized by hyperglycemia, high‐anion‐gap metabolic acidosis, and ketonemia. Hypernatremia in DKA is uncommon and typically reflects disproportionate free water loss. Arginine vasopressin resistance (AVP‐R), previously known as nephrogenic diabetes insipidus, may occur in ...
Reem Shihab, May Shihab, Hala O. Abdallah, Suha Nori, Obay Mashaqi, Semonti Nandi   +5 more
wiley   +1 more source

Nephrotoxicity and Modern Volatile Anesthetics: A Narrative Review

Toxics
Volatile anesthetics, while increasingly utilized in intensive care medicine, are associated with significant renal adverse effects. A critical safety concern—particularly with sevoflurane—involves its potential impact on renal function ...
Benedicte Hauquiert, Aurelien Gonze, Thibault Gennart, Emily Perriens, Sydney Blackman, Nathan De Lissnyder, Arnaud Robert, Julien Moury, Gauthier Nendumba, Ilann Oueslati, Priscilla Gillis, Ovidiu Vornicu, Anne-Sophie Dincq, Pierre Bulpa, Isabelle Michaux, Patrick M. Honore   +15 more
doaj   +1 more source

Dual Aetiology of Diabetes Insipidus in Pregnancy: Vasopressinase‐Mediated and Central Mechanisms

Case Reports in Nephrology, Volume 2026, Issue 1, 2026.
Diabetes insipidus (DI) is a heterogeneous disorder characterised by polyuria and polydipsia due to impaired arginine vasopressin (AVP) secretion or action. We describe a 36‐year‐old pregnant woman who presented at 28 weeks’ gestation with weakness, severe hypokalaemia from renal potassium wasting, hypernatraemia and polyuria with dilute urine ...
Philani Ezekiel Mkhize, Pauli van Heerden, Tholakele Sabela, Mogamat Razeen Davids, Mogamat-Yazied Chothia, Ze’ev Korzets   +5 more
wiley   +1 more source

AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus

Nature Communications, 2018
Patients suffering from congenital nephrogenic diabetes insipidus (NDI) fail to concentrate urine due to mutations in vasopressin type 2 receptor (V2R). Here Ando et al.
Fumiaki Ando, Shuichi Mori, Naofumi Yui, Tetsuji Morimoto, Naohiro Nomura, Eisei Sohara, Tatemitsu Rai, Sei Sasaki, Yoshiaki Kondo, Hiroyuki Kagechika, Shinichi Uchida   +10 more
doaj   +1 more source

Use of copeptin in interpretation of the water deprivation test

Endocrinology, Diabetes & Metabolism, 2023
Introduction Currently, the water deprivation test remains the standard method for distinguishing primary polydipsia (PP) from cranial diabetes insipidus (cDI) and nephrogenic diabetes insipidus (nDI). There is increasing interest in a direct estimate of
Matthew Rowe, Nishchil Patel, Jinny Jeffery, Daniel Flanagan   +3 more
doaj   +1 more source